Establishment of research basis for nutrigenomics-based nutritional education

2011 Fiscal Year Final Research Report

• Project/Area Number: 22650181
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Eating habits, studies on eating habits
• Research Institution: The University of Tokushima
• Principal Investigator: TAKETANI Yutaka 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授 (30263825)
• Research Collaborator: OMINAMI Hirokazu 徳島大学, 大学院・栄養生命科学教育部, 大学院生 ; TAN Vu van 徳島大学, 大学院・栄養生命科学教育部, 大学院生 ; TOMOYO Kitamura 徳島大学, 大学院・栄養生命科学教育部, 大学院生 ; AMO Kikuko 徳島大学, 大学院・栄養生命科学教育部, 大学院生 ; TANIMURA Ayako 徳島大学, 大学院・栄養生命科学教育部, 大学院生 ; TANAKA Terumi 徳島大学, 大学院・栄養生命科学教育部, 大学院生 ; HORIE Daisuke 徳島大学, 大学院・栄養生命科学教育部, 大学院生 ; YAMASAKI Michiyo 徳島大学, 大学院・栄養生命科学教育部, 大学院生 ; UEDA Haruka 徳島大学, 大学院・栄養生命科学教育部, 大学院生 ; ABULI Maerujianghan 徳島大学, 大学院・栄養生命科学教育部, 大学院生
• Project Period (FY): 2010 – 2011
• Keywords: 栄養学 / 食品 / 循環器疾患 / 食育 / リン / 遺伝因子 / 生活習慣病

Research Abstract

In this study, we attempted to establish a strategy to development a new procedure for nutritional education based on molecular nutrition with genetic factors affecting eating habits, behaviors, and pathogenesis of life-style related diseases. As a representative research model, we investigated the relationships between genetic factors and dietary phosphate intake, post-prandial serum P levels, endothelial function, and appetite. Our results suggest that our strategy was effective to analyze the individual differences in the relationships between dietary intake and nutrient metabolism, eating behavior, serum markers, or patho-physiological function with genetic factors. The strategy may enable us to develop a tailor-made strategy of nutritional education to prevent various life-style related diseases.

Research Products

• [Journal Article] リン酸トランスポーターと心血管疾患 (2010)
  • Author(s): 竹谷豊
  • Journal Title: 生化学 Volume: Vol.82、No.8 Pages: 727-729
  • URL: http://wwwsoc.nii.ac.jp/jbiochem/magazine/82-08-05.pdf
  • Peer Reviewed
• [Presentation] Hyperphosphatemia causes endothelial dysfunction by inhibiting Akt-endothelial nitric oxide synthase pathway in chronic kidney disease rats (2011)
  • Author(s): Yutaka Taketani, Tan Vu Van, Eriko Watari, Tomoyo Kitamura, Terumi Tanaka, Abuli Maerujianghan, Hirokazu Ohminami, Hironori Yamamoto, Ken-ichi, Miyamoto, Eiji Takeda
  • Organizer: American Heart Association Scientific Sessions2011
  • Place of Presentation: Orange County Convention Center(Orlando, FL, USA)
  • Year and Date: 20111112-16
• [Presentation] Elevated Extracellular Phosphate Levels Down-Regulate Both Akt and AMP-Dependent Kinase in Endothelial Cells (2011)
  • Author(s): Yutaka Taketani, Tomoyo Kitamira, Eriko Watari, Tan Vu Van, Terumi Tanaka, Yukari Mori, Michiyo Yamasaki, Haruka Ueda, Hironori Yamamoto, Eiji Takeda
  • Organizer: American Society of Nephrology, Kidney Week2011
  • Place of Presentation: Philadelphia Convention Center(Philadelphia, PA, USA)
  • Year and Date: 20111110-13
• [Presentation] 慢性腎臓病における高リン血症と心血管疾患 (2011)
  • Author(s): 竹谷豊、首藤恵泉、山本浩範、武田英二
  • Organizer: 第41回日本腎臓学会西部学術集会
  • Place of Presentation: あわぎんホール(徳島市)
  • Year and Date: 20110930-1001
• [Presentation] リン代謝恒常性の破綻と血管疾患 (2011)
  • Author(s): 竹谷豊
  • Organizer: 第50回日本栄養・食糧学会近畿支部大会
  • Place of Presentation: 近畿大学(奈良市)
  • Year and Date: 2011-10-15
• [Presentation] 栄養学的に見た高リン血症の問題 (2010)
  • Author(s): 竹谷豊
  • Organizer: 第13回東海ROD研究会
  • Place of Presentation: キャッスルプラザ(名古屋市)
  • Year and Date: 2010-07-31