2011 Fiscal Year Final Research Report
Observations and Analysis of Rotary Movement of a Supramolecular Motor by Single-Molecular Imaging through Actual Time.
| Project/Area Number |
22655034
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Polymer chemistry
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
AOKI Hiroyuki 京都大学, 先端医工学研究ユニット, 准教授 (90343235)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 超分子化学 / 分子モーター / 単一分子計測 / 回転運動観察 / 回転制御 |
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| Research Abstract |
Biological molecular motors such as muscle fibers, flagella and cilia are precisely designed in nature, and are reminiscent of microscale electronic and mechanical devices. Inspired by direct observations of rotary molecular motor systems, some researchers have tried to directly observe artificial molecular motors. On the contrary, even smaller artificial molecular motors are extremely difficult to see, and thus, additional visualization techniques are necessary to observe rotational behavior. Rotaxane has a suitable structure to construct molecular motors. Herein we observe a single rotaxane molecule based onα-cyclodextrin(α-CD) attached to a fluorescence probe on glass substrates and estimate the rotary movement ofα-CD as a rotor, which was measured by total internal reflection fluorescence microscopy(TIRFM). Herein, we observe the rotary movement of
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