2011 Fiscal Year Final Research Report
Development of novel immunotherapy by using of human iPS cells of an antigen-specific T-cell origin
| Project/Area Number |
22659058
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
General medical chemistry
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Keywords | 抗原特異的T細胞 / iPS細胞 / 幹細胞 / T細胞の分化誘導 |
|---|
| Research Abstract |
Adoptive immunotherapy with antigen-specific T cells expressing a limited TCR repertoire is a promising approach to fighting various types of cancer and chronic viral infections ; however, the effectiveness of this therapy declines due to exhaustion of the antigen-specific T cells. To overcome this problem, we have explored the potential of induced pluripotent stem(iPS) cell technology and have generated T cell-derived iPS(T-iPS) cells. Furthermore, we have succeeded in redifferentiating T-iPS cells into T lineage cells. As was expected, the invariance of the antigen specificity was evidenced by the fact that the TCR gene rearrangement patterns in the redifferentiated T lineage cells were identical to those in the original T cell. These findings suggest that regeneration of antigen-specific immune systems using iPS cell technology will shed new light on the field of adoptive immunotherapy.
|
Research Products
(17 results)
-
[Journal Article] Generation of germline-competent rat induced pluripotent stem cells2011
Author(s)
Hamanaka S, Yamaguchi T, Kobayashi T, Kato-Itoh M, Yamazaki S, Sato H, Umino A, Wakiyama Y, Arai M, Sanbo M, Hirabayashi M, Nakauchi H
-
Journal Title
PLoS One
Volume: 6
Pages: e22008
DOI
Peer Reviewed
-
[Journal Article] Development of defective and persistent sendai virus vector : a unique gene delivery/expression system ideal for cell reprogramming2011
Author(s)
Nishimura K, Sano M, Ohtaka M, Furuta B, Umemura Y, Nakajima Y, Ikehara Y, Kobayashi T, Segawa H, Takayasu S, Sato H, Motomura K, Uchida E, Kanayasu-Toyoda T, Asashima M, Nakauchi H, Yamaguchi T, Nakanishi M
-
Journal Title
J Biol Chem
Volume: 11
Pages: 476-71
DOI
Peer Reviewed
-
[Journal Article] Reduction of N-Glycolylneuraminic Acid in Human Induced Pluripotent Stem Cells Generated or Cultured under Feeder-and Serum-Free Defined Conditions2010
Author(s)
Hayashi Y, Chan T, Warashina M, Fukuda M, Ariizumi T, Okabayashi K, Takayama N, Otsu M, Eto K, Furue MK, Michiue T, Ohnuma K, Nakauchi H, Asashima M
-
Journal Title
PLoS One
Volume: 23
Pages: e14099
DOI
Peer Reviewed
-
[Journal Article] Transient activation of c-MYC expression is critical for efficient platelet generation from human induced pluripotent stem cells2010
Author(s)
Takayama N, Nishimura S, Nakamura S, Shimizu T, Ohnishi R, Endo H, Yamaguchi T, Otsu M, Nishimura K, Nakanishi M, Sawaguchi A, Nagai R, Takahashi K, Yamanaka S, Nakauchi H, Eto K
-
Journal Title
J Exp Med
Volume: 20
Pages: 2817-30
DOI
Peer Reviewed
-
[Journal Article] Generation of rat pancreas in mouse by interspecific blastocyst injection of pluripotent stem cells2010
Author(s)
Kobayashi T, Yamaguchi T, Hamanaka S, Kato-Itoh M, Yamazaki Y, Ibata M, Sato H, Lee YS, Usui J, Knisely AS, Hirabayashi M, Nakauchi H
-
Journal Title
Cell
Volume: 3
Pages: 787-99
DOI
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
