2011 Fiscal Year Final Research Report
Protein processing system-regulating microRNA in gastrointestinal carcinogenesis and its clinical application
Project/Area Number |
22659074
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Single-year Grants |
Research Field |
Human pathology
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Research Institution | Hiroshima University |
Principal Investigator |
YASUI Wataru 広島大学, 大学院・医歯薬学総合研究科, 教授 (40191118)
|
Project Period (FY) |
2010 – 2011
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Keywords | 消化管癌 / 蛋白プロセッシング / マイクロRNA / シグナルペプチダーゼ / 診断.治療 |
Research Abstract |
In protein processing system, SPC18, but not SPC21, regulated secretion of EGF and TGFαby cancer cells and activated EGFR. SPC18-positive gastric cancer patients, monitored by immunostaining using anti-SPC18 antibody produced by our laboratory, showed worse prognosis. Down-regulation of miR-143 by DNA methylation regulated TGFβexpression.
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Research Products
(34 results)
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[Journal Article] Deficiency of claudin-18 causes paracellular H+ leakage, up-regulation of interleukin-1beta, and atrophic gastritis in mice Isaka Y and Tsukita S : Deficiency of claudin-18 causes paracellular H+ leakage2012
Author(s)
Hayashi D, Tamura A, Tanaka H, Yamazaki Y, Watanabe S, Suzuki K, Suzuki K, Yasui W, Rakugi H,
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Journal Title
up-regulation of interleukin-1beta and atrophic gastritis in mice.
Volume: 142
Pages: 292-304
Peer Reviewed
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[Journal Article] A functional SNP in MUC1, at chromosome 1q22, determines susceptibility to diffuse-type gastric cancer Short title2011
Author(s)
Saeki N, Saito A, Choi IJ, Matsuo K, Ohnami S, Totsuka H, Chiku S, Kuchiba A, Lee YS, Yoon KA, Kook MC, Park SR, KimYW, Tanaka H, Tajima K, Hirose H, Tanioka F, Matsuno Y, Sugimura H, KatoS, Nakamura T, Nishina T, Yasui W, Aoyagi K, Sasaki H, Yanagihara K, KataiH, Shimoda T, Yoshida T, Nakamura Y, Hirohashi S and Sakamoto H
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Journal Title
MUC1is a gastric cancersusceptibility gene. Gastroenterology
Volume: 140
Pages: 892-902
Peer Reviewed
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[Journal Article] Chemoprevention by nonsteroidalanti-inflammatory drug eliminates oncogenic intestinal stem cells via SMAC-dependent apoptosis2010
Author(s)
Qui W, Wang X, Leibowitz, Liu H, BarkerN, Okada H, Oue N, Yasui W, Clevers H, Schoen RE, Yu J and Zhang L
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Journal Title
Proc Natl Acad Sci USA
Volume: 107
Pages: 20027-20032
Peer Reviewed
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[Journal Article] Calin GA and Croce CM : Relation between micro RNAexpression and progression and prognosis of gastric cancer2010
Author(s)
Ueda T, Volinia S, Okumura H, Shimizu M, Taccioli C, Rossi S, Alder H, Liu CG, Oue N, Yasui W, Yoshida K, Sasaki H, Nomura S, Seto Y, Kaminishi M
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Journal Title
a microRNA expression analysis. Lancet Oncol
Volume: 11
Pages: 136-146
Peer Reviewed
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