2011 Fiscal Year Final Research Report
RNA modification and self-discrimination : A possible link to the pathogenesis of autoimmune disease
| Project/Area Number |
22659186
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | University of Miyazaki |
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Principal Investigator |
KENMOCHI Naoya 宮崎大学, フロンティア科学実験総合センター, 教授 (00133124)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKAYANAGI Atushi 慶應義塾大学, 医学部, 講師 (80245464)
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| Project Period (FY) |
2010 – 2011
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| Keywords | RNA修飾 / ノンコーディングRNA / 抗RNA抗体 / リボソームRNA / snoRNA |
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| Research Abstract |
Non-coding RNAs undergo various posttranscriptional modifications. To investigate the physiological relevance of RNA modifications in autoimmune diseases, we generated artificial anti-RNA antibodies that bind to the epitope for patient autoantibodies and developed a zebrafish model of defective RNA modifications. Impaired RNA modification led to severe morphological defects and embryonic lethality in zebrafish, which suggests that RNA modifications play an important role in vertebrate development.
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[Journal Article] Loss of ribosomal RNA modification causes developmental defects in zebrafish2012
Author(s)
Higa-Nakamine, S., Suzuki, T., Uechi, T., Chakraborty, A., Nakajima, Y., Nakamura, M., Hirano, N., Suzuki, T. and Kenmochi, N.
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Journal Title
Nucleic Acids Res
Volume: 40
Pages: 391-398
Peer Reviewed
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