2011 Fiscal Year Final Research Report
Development of evaluation method of drug safety for children using cultured cells and tandem mass spectrometry
| Project/Area Number |
22659195
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatrics
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| Research Institution | Shimane University |
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Principal Investigator |
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| Research Collaborator |
HASEGAWA Yuki 島根大学, 医学部, 助教 (00362921)
KOBAYASHI Hironori 島根大学, 医学部, 助教 (70397868)
MUSHIMOTO Yuichi 島根大学, 医学部, 助教 (90467712)
PUREVSUREN Jamiyan 島根大学, 医学部, 外国人特別研究員
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| Project Period (FY) |
2010 – 2011
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| Keywords | 脂肪酸代謝異常 / インフルエンザ脳症 / 薬剤安全性 / β酸化能 / ベザフィブレート |
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| Research Abstract |
There are some drugs which may occasionally toxic for children, despite non-toxic for adults. We use a method, in vitro probe acylcarnitine(IVP) assay, using cultured fibroblasts and tandem mass spectrometry(MS/MS) to evaluate fatty acid oxidation(FAO) capacity and toxicity of drugs. Cells from various FAO disorders(medium-to long-chain disorders) were used, and the following results were obtained : Aspirin(antipyretic), and valproic acid(anti-epileptic drug) potentially caused some inhibition of FAO in cells from impaired FAO patients. Bezafibrate(hypolipidemic drug) significantly improved FAO in cells from FAO disorders. Bezafibrate can be a new treatment option for FAO disorders.
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[Journal Article] Retrospective review of Japanese sudden unexpected death in infancy : The importance of metabolic autopsy and expanded newborn screening2011
Author(s)
Yamamoto T, Tanaka H, Kobayashi H, Okamura K, Tanaka T, Emoto Y, Sugimoto K, Nakatome M, Sakai N, Kuroki H, Yamaguchi S, Matoba R
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Journal Title
Molecular Genetics and Metabolism
Volume: 102(4)
Pages: 399-406
DOI
Peer Reviewed
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[Presentation] A hypolipidemic drug, bezafibrate, can be a new treatment option for mitochondrial fatty acid oxidation disorders2011
Author(s)
Yamaguchi S, Li H, Purevsuren J, Mushimoto Y, Kobayashi H, Hasegawa Y, Fukao T, Fukuda S
Organizer
The 7th Congress of Asian Society for Pediatric Research
Place of Presentation
Colorado Convention Center(Denver, USA)
Year and Date
2011-04-30
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