Mouse models of Autoimmune hearing loss generated by a transgenic approach and its implication

2011 Fiscal Year Final Research Report

• Project/Area Number: 22659309
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Otorhinolaryngology
• Research Institution: Keio University
• Principal Investigator: OGAWA Kaoru 慶應義塾大学, 医学部, 教授 (00169179)
• Co-Investigator(Kenkyū-buntansha): FUJIOKA Masato 慶應義塾大学, 医学部, 共同研究員 (70398626) ; KANZAKI Sho 慶應義塾大学, 医学部, 講師 (50286556)
• Project Period (FY): 2010 – 2011
• Keywords: 耳科学 / トランスレーショナルリサーチ / 自己免疫 / 難聴 / 免疫学

Research Abstract

Autoimmune hearing loss models were established by generating a transgenic mouse (Math-HA) that specifically expresses HA antigen in the inner ear hair cells. By an adoptive transfer of lymphocytes derived from CL4mice, the mice suffered hearing loss at h

Research Products

• [Journal Article] Role of Tinnitus Handicap Inventory in Evaluating Tinnitus Severity and Estimating Comorbid (2011)
  • Author(s): Oishi N, Shinden S, Kanzaki S,Saito H, Inoue Y,Ogawa K
  • Journal Title: Depression and Anxiety J Int Audiology
  • Peer Reviewed
• [Journal Article] Application of autogenic training in patients with Meniere disease (2011)
  • Author(s): Goto F, Nakai K, Ogawa K
  • Journal Title: Eur Arch Otorhinolaryngol
  • Peer Reviewed
• [Journal Article] Pure tone auditory thresholds can change according to duration of interrupted tones in patients with psychogenic hearing loss (2011)
  • Author(s): Oishi N, Inoue Y, Ogawa K他3名
  • Journal Title: Acta Otolaryngol.
  • Peer Reviewed
• [Journal Article] Influence of depressive symptoms, state anxiety, and pure tone thresholds on the Tinnitus Handicap Inventory in Japan (2011)
  • Author(s): Oishi N, Shinden S, Kanzaki S,Saito H, Inoue Y, Ogawa K
  • Journal Title: Int J Audiology
  • Peer Reviewed
• [Journal Article] Impaired vibration of auditory ossicles in osteopetrotic mice (2011)
  • Author(s): Kanzaki S,Ogawa K, Momose A, Matsuo K他5名
  • Journal Title: Am J Pathol Volume: 178(3) Pages: 1270-8
  • Peer Reviewed
• [Journal Article] Notch Signaling Alters Sensory of Neuronal Cell Fate Specification of Inner Ear Stem Cells (2011)
  • Author(s): Fujioka M, Jeon SJ, Kim SC, Edge AS
  • Journal Title: J.Neurosci. Volume: 31(23) Pages: 8351-8
  • Peer Reviewed
• [Journal Article] Generating mouse models of degenerative diseases using Cre/lox-mediated in vivo mosaic cell ablation (2011)
  • Author(s): Fujioka M,Tokano H, Fujioka SK, Okano H, Edge AS
  • Journal Title: J. Clin. Invest. Volume: 121(6) Pages: 2462-9
  • Peer Reviewed
• [Journal Article] Expression and Function of Sox21 During Mouse Cochlea Development. (2011)
  • Author(s): Hosoya M, Fujioka M,Matsuda S, Ogawa K, Okano HJ, Okano H他
  • Journal Title: Neurochem Res Volume: 36(7) Pages: 1261-9
  • Peer Reviewed
• [Journal Article] Repetitive transcranial magnetic stimulation (rTMS) for treatment of chronic tinnitus. (2011)
  • Author(s): Minami SB, Shinden S, Kanzaki S,Inoue Y, Ogawa K.他5名
  • Journal Title: Auris Nasus Larynx Volume: 38(3) Pages: 301-6
  • Peer Reviewed
• [Journal Article] Effects of selective serotonin reuptake inhibitor on treating tinnitus in patients stratified for presence of depression or anxiety. (2010)
  • Author(s): Oishi N, Kanzaki S, Ogawa K他3名
  • Journal Title: Audiol Neurootol Volume: 15(3) Pages: 187-93
  • Peer Reviewed
• [Journal Article] Long-term prognosis of low-frequency hearing loss and predictive factors for the 10-year outcome (2010)
  • Author(s): Oishi N, Kanzaki S, Ogawa K他
  • Journal Title: Otolaryngol Head Neck Surg
  • Peer Reviewed
• [Journal Article] Physical and physiological effects on otoacoustic emissions in hypobaric hypoxia. (2010)
  • Author(s): Ide R, Harada T, Kanzaki S, Ogawa K
  • Journal Title: ORL J Otorhinolaryngol Relat Spec Volume: 72(4) Pages: 225-32
  • Peer Reviewed
• [Journal Article] Long-term prognosis of low-frequency hearing loss and predictive factors for the 10-year outcome (2010)
  • Author(s): Oishi N, Kanzaki S, Ogawa K
  • Journal Title: Otolar Head Neck Surg Volume: 142(4) Pages: 565-9
  • Peer Reviewed
• [Journal Article] Blockade of interleukin-6 signaling suppressed cochlear inflammatory response and improved hearing impairment in noise-damaged mice cochlea (2010)
  • Author(s): Wakabayashi K, Fujioka M, Kanzaki S,Okano HJ, Ogawa K, Okano H他.
  • Journal Title: Neurosci Res Volume: 66(4) Pages: 345-52
  • Peer Reviewed
• [Presentation] A transgenic mouse model for autoimmune hearing loss due to a "failure" of immunologic tolerance to the inner ear hair cell (2011)
  • Author(s): Fujioka M
  • Organizer: HMS-Keio-Northwestern Joint meeting for inner ear autoimmunity
  • Place of Presentation: Boston
  • Year and Date: 2011-03-22
• [Presentation] 内耳基礎研究の基礎講座「内耳トランスレーショナルリサーチの心強いツールたち～分子生物学から実験動物まで～ (2010)
  • Author(s): 藤岡正人
  • Organizer: 第29回聴覚生理研究会
  • Place of Presentation: 愛媛県松山: 耳科学会
  • Year and Date: 2010-10-07