2011 Fiscal Year Final Research Report
Mouse models of Autoimmune hearing loss generated by a transgenic approach and its implication
Project/Area Number |
22659309
|
Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
Allocation Type | Single-year Grants |
Research Field |
Otorhinolaryngology
|
Research Institution | Keio University |
Principal Investigator |
OGAWA Kaoru 慶應義塾大学, 医学部, 教授 (00169179)
|
Co-Investigator(Kenkyū-buntansha) |
FUJIOKA Masato 慶應義塾大学, 医学部, 共同研究員 (70398626)
KANZAKI Sho 慶應義塾大学, 医学部, 講師 (50286556)
|
Project Period (FY) |
2010 – 2011
|
Keywords | 耳科学 / トランスレーショナルリサーチ / 自己免疫 / 難聴 / 免疫学 |
Research Abstract |
Autoimmune hearing loss models were established by generating a transgenic mouse (Math-HA) that specifically expresses HA antigen in the inner ear hair cells. By an adoptive transfer of lymphocytes derived from CL4mice, the mice suffered hearing loss at h
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