2013 Fiscal Year Final Research Report
Suppression of meiosis by mRNA degradation
| Project/Area Number |
22687013
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Molecular biology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
SUGIYAMA Tomoyasu 筑波大学, 生命領域学際研究センター, 研究員 (80503490)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | 減数分裂 / RNA分解 / 核内構造体 |
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| Research Abstract |
The mechanism(s) by which untimely meiosis is prevented in mitotic cells is not understood fully. Using the fission yeast Schizosaccharomyces pombe, we studied mRNA degradation-based suppression of meiosis.
We isolated Red1, which forms nuclear foci, and found that 1) Red1 promotes selective degradation of meiotic mRNAs in vegetative cells; 2) Red1 forms a complex with two novel proteins Red2 and Red3, both of which are essential for meiotic mRNA elimination; 3) Red5 facilitates meiotic mRNA decay after the Red1 complex adds poly(A) tails to target mRNAs; and 4) Rhn1, which is homologous to a transcription termination factor, suppresses meiotic mRNAs in growing cells, and Cids-2, an Rhn1 homolog in C. elegans, also suppress germ-specific transcripts in somatic cells. These results suggest that meiotic mRNA suppression is a common mechanism by which meiosis is inhibited in eukaryotes.
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Research Products
(18 results)
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[Remarks] A. 受賞 筑波大学における間接経費を伴う外部資金獲得に係る報奨金(2013年3月)
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[Remarks] A. 受賞 第62回日本細胞生物学会大会日本細胞生物学会若手優秀発表賞(2010年5月)
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[Remarks] B. マスコミによる報道等日刊工業新聞掲載(2010年3月3日)
