2013 Fiscal Year Final Research Report
A novel model of epilepsy: Familial spontaneous epileptic cats
| Project/Area Number |
22688027
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Clinical veterinary science
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| Research Institution | Nippon Veterinary and Life Science University |
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Principal Investigator |
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | てんかん / 動物モデル / 遺伝 / ネコ / 脳波 / MRI |
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| Research Abstract |
This sequential study is performed to establish a family line of spontaneous epileptic cat (FSEC) as a novel animal model of epilepsy. FSEC is thought to be inherited as autosomal recessive and can maintain the strain only affected animals. The seizure types of FSEC correspond to human mesial temporal lobe epilepsy and existing model of temporal lobe epilepsy (kindling, kainate, or EL mice), ie., limbic focal seizures with/without secondarily generalizations. Electroencephalographic and MRI features also show that the epileptogenic zone of FSEC exist in the amygdala and/or hippocampus. We are convinced that FSEC will be a precious and important animal model of "true" (spontaneous and genetic) epilepsy.
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