Analysis of the mechanisms of an RNase, Zc3h12a-mediated immune regulation.

2012 Fiscal Year Final Research Report

• Project/Area Number: 22689016
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Immunology
• Research Institution: Kyoto University (2012); Osaka University (2010-2011)
• Principal Investigator: TAKEUCHI Osamu 京都大学, ウイルス研究所, 教授 (10379092)
• Project Period (FY): 2010 – 2012
• Keywords: 炎症 / サイトカイン / mRNA安定性 / 自然免疫 / シグナル伝達

Research Abstract

In this study, we examined the role of an RNase Regnase-1 (also known as Zc3h12a) in the prevention of the development of autoimmune diseases, and found that Regnase-1 expressed in T cells as well as macrophages is critical for this task. Furthermore, Regnase-1 protein expression is dramatically regulated in the course of inflammation in these cells.

Research Products

• [Journal Article] Malt1-Induced Cleavage of Regnase-1 in CD4+ Helper T Cells Regulates Immune Activation (2013)
  • Author(s): Uehata T, Iwasaki H, Vandenbon A, Matsushita, K, Hernandez Cuellar E, Kuniyoshi K, Satoh T, Mino T, Suzuki Y, Standley DM, Tsujimura T, Rakugi H, Isaka Y, Takeuchi O and Akira S
  • Journal Title: Cell Volume: 23;153 Pages: 1036-49
  • DOI: doi:10.1016/j.cell.2013.04.034
  • Peer Reviewed
• [Journal Article] Critical Role of AZI2 in GM-CSF-Induced Dendritic Cell Differentiation (2013)
  • Author(s): Fukasaka M, Ori D, Kawagoe T, Uematsu S, Maruyama K, Okazaki T, Kozaki T, Imamura T, Tartey S, Mino T, Satoh T, Akira S, Takeuchi O
  • Journal Title: J Immunol Volume: 190 Pages: 5702-11
  • DOI: doi:10.4049/jimmunol.1203155
  • Peer Reviewed
• [Journal Article] Critical role of Trib1 in differentiation of tissue-resident M2-like macrophages (2013)
  • Author(s): Satoh T, Kidoya H, Naito H, Yamamoto M,Takemura N, Nakagawa K, Yoshioka Y, Morii E, Takakura N, Takeuchi O, Akira S
  • Journal Title: Nature Volume: 495 Pages: 524-8
  • Peer Reviewed
• [Journal Article] Essential Roles of K63-Linked Polyubiquitin-Binding Proteins TAB2 and TAB3 in B Cell Activation via MAPKs (2013)
  • Author(s): Ori D, Kato H, Sanjo H, Tartey S, Mino T, Akira, S, Takeuchi O
  • Journal Title: J Immunol Volume: 190 Pages: 4037-45
  • DOI: DOI:10.4049/jimmunol.1300173
  • Peer Reviewed
• [Journal Article] The transcription factor Jdp2 controls bone homeostasis and antibacterial immunity by regulating osteoclast and neutrophil differentiation (2012)
  • Author(s): Maruyama K, Fukasaka M, Vandenbon A, Saitoh, T, Kawasaki T, Kondo T, Yokoyama KK, Kidoya, H., Takakura N,Standley D, Takeuchi O, Akira S
  • Journal Title: Immunity Volume: 37 Pages: 1024-36
  • DOI: DOI:10.1016/j.immuni.2012.08.022.
  • Peer Reviewed
• [Journal Article] TRAF family member-associated NF-κB activator (TANK) is a negative regulator of osteoclastogenesis and bone formation (2012)
  • Author(s): Maruyama K, Kawagoe T, Kondo T, Akira S, Takeuchi O
  • Journal Title: J Biol Chem Volume: 287 Pages: 29114-24
  • DOI: DOI:10.1074/jbc.M112.347799
  • Peer Reviewed
• [Journal Article] The IκB Kinase Complex Regulates the Stability of Cytokine-encoding mRNA Induced by TLR-IL-1R by Controlling Degradation of Regnase-1 (2011)
  • Author(s): Iwasaki, H., Takeuchi, O., Teraguchi, S., Matsushita, K., Uehata, T., Kuniyoshi, K., Satoh, T., Saitoh, T., Matsushita, M., Standley, D.M., Akira, S
  • Journal Title: Nat. Immunol Volume: 12 Pages: 1167-1175
  • DOI: doi:10.1038/ni.2137.
  • Peer Reviewed
• [Journal Article] IκBζ Is Essential for Natural Killer Cell Activation in Response to IL-12 and IL-18 (2010)
  • Author(s): Miyake, T., Satoh, T., Kato, H., Matsushita, K., Kumagai, Y., Vandenbon, A., Tani, T., Muta, T., Akira, S., Takeuchi, O.
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: 107 Pages: 17680-17685
  • DOI: doi:10.1073/pnas.1012977107.
  • Peer Reviewed
• [Journal Article] Pattern recognition receptors and inflammation. (2010)
  • Author(s): Takeuchi O, Akira S
  • Journal Title: Cell Volume: 140(6) Pages: 805-20
  • DOI: doi:10.1016/j.cell.2010.01.022.
• [Presentation] RNA分解酵素Regnase-1による自然免疫制御 (2012)
  • Author(s): 竹内 理
  • Organizer: 日本生化学会大会
  • Place of Presentation: 福岡
  • Year and Date: 20121214-16
• [Presentation] Posttranscriptional control of inflammation (2012)
  • Author(s): Takeuchi, O
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 福岡
  • Year and Date: 20121211-14
• [Presentation] Systems Immunology-最近の動向 (2012)
  • Author(s): Takeuchi, O.
  • Organizer: Annual Meeting of Japanese Society for Immunology
  • Place of Presentation: Kobe
  • Year and Date: 20121121-22
• [Presentation] Recognition of viral infection by innate immunity (2012)
  • Author(s): Takeuchi, O
  • Organizer: Single Topic Conference "Hepatitis C: Best Practice Based on Science"
  • Place of Presentation: Tokyo
  • Year and Date: 20121121-22
• [Presentation] Posttranscriptional control of inflammation by an Rnase, Regnase-1 (2012)
  • Author(s): Takeuchi, O
  • Organizer: IEIIS2012
  • Place of Presentation: Tokyo
  • Year and Date: 20121023-26
• [Presentation] Posttranscriptional control of inflammation by an RNase, Regnase-1. (2012)
  • Author(s): Takeuchi, O
  • Organizer: 19th East Asia Joint Symposium on Biomedical Research
  • Place of Presentation: Seoul
  • Year and Date: 20120823-24
• [Remarks] ホームページ
  • URL: http://www.virus.kyoto-u.ac.jp/Lab/Takeuchi_HP/index.html