2011 Fiscal Year Final Research Report
Neuron-glia interaction during cerebellar development The role of Ca-permeable AMPA receptors
| Project/Area Number |
22700431
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Fusional basic brain science
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| Research Institution | Gunma University |
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Principal Investigator |
HOSOI Nobutake 群馬大学, 大学院・医学系研究科, 助教 (90543570)
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| Project Period (FY) |
2010 – 2011
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| Keywords | ニューロングリア相互作用 / 小脳 / Ca透過型AMPA受容体 / バーグマングリア / GluR2 / プルキンエ細胞 |
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| Research Abstract |
Cerebellar Bergmann glial cells have Ca-permeable AMPA receptors and can be involved in formation and development of neuronal circuit via neuron-glia interactions mediated by Ca. To elucidate the functional role of Ca-permeable AMPA receptors in cerebellar glial cells, I attempted to develop a method in which glial Ca-permeable AMPA receptors are turned Ca-impermeable during cerebellar development. Using lentiviral vectors with truncated GFAP promoters, I succeeded in expressing a GluR2 gene in glial cells effectively, with no change in tropism.
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