2011 Fiscal Year Final Research Report
Development of estimation method of rupture strength of aortic aneurysms from their structure of tissue
| Project/Area Number |
22700467
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Nagoya Institute of Technology |
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Principal Investigator |
SUGLTA Shukel 名古屋工業大学, 工学研究科, 助教 (20532104)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 生物・生体工学 / 生体材料 / 細胞・組織 |
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| Research Abstract |
To predict rupture of the aortic aneurysms from their microscopic structures, the relationship between rupture and structure of collagen in aortic wall was investigated. Firstly, a method to quantify local volume and direction of collagen fibers was established. Then, thin slices of the thoracic aortas were biaxially stretched during observation of collagen structure under a microscope. As a result, we found that local microscopic structures of collagen fibers strongly influenced its local strains, indicating that collagen structures may have important role on rupture of the aorta.
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