2012 Fiscal Year Final Research Report
Development of a new approach of physical therapy based on pathophysiologic mechanisms for chronic pain associated with limb immobilization
| Project/Area Number |
22700559
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Aichi Medical University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 慢性痛 / 可塑性 / ミクログリア / アストロサイト / 動物モデル / 不活動 / ギプス 固定 |
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| Research Abstract |
At the present, there is no successful therapy for certain types of refractory chronic widespread pain (CWP), such as complex regional pain syndrome I (CRPS I), and fibromyalgia. We developed the chronic post-cast pain (CPCP) model for the development of a new promising physiotherapy approach based on elucidating the pathology mechanisms for this CWP. We found that the spinal microglial activations play a role in the expansion of the mechanical hyperalgesia to the contralateral side, and that the spinal astrocyte activations are a factor in the maintenance of the mechanical hyperalgesia. It was suggested that the ischemic reperfusion injury/oxidative stress in the fixed hindlimb triggers the onset of the mechanical hyperalgesia and the spinal glial activations in CPCP rats. Further investigation based on this finding may lead to the creation of a basis for clinical application of physiotherapy for CWP.
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[Journal Article] Treadmill running and static stretchingimprove long-lasting hyperalgesia2013
Author(s)
Morimoto A,Winaga Handriadi,Sakurai H,Ohmichi M, Yoshimoto T,Ohmichi Y,Matsui T,Ushida T,Okada T,Sato J
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Journal Title
jointlimitation, and muscle atrophy induced bycast immobilization in rats Neuroscience letters
Volume: 8, 534
Pages: 295-300
Peer Reviewed
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[Journal Article] Frequency components ofsystolic blood pressure variability reflectvasomotor and cardiac sympathetic functions in conscious rats2011
Author(s)
Yoshimoto T, Eguchi K, Sakurai H, Ohmichi Y,Hashimoto T, Ohmichi M, Morimoto A,Yamaguchi Y, Ushida T, Iwase S, Sugenoya J,Kumazawa T
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Journal Title
The journal of physiological sciences
Volume: 61
Pages: 373-83
Peer Reviewed
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