2011 Fiscal Year Final Research Report

Study of novel lipid-lowering effects of sesaminol, a sesame lignan

Research Project

Project/Area Number	22700752
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Eating habits, studies on eating habits
Research Institution	University of Miyazaki
Principal Investigator	NISHIZONO Shoko 宮崎大学, 産学・地域連携センター, 准教授 (40336970)
Project Period (FY)	2010 – 2011
Keywords	ゴマリグナン / セサミノールアグリコン / 脂質代謝 / ラット
Research Abstract	Sesaminol is a sesame lignin and is present most exclusively occurring as sesaminol triglucoside in sesame seed. In this study, effect of sesaminol aglycone on lipid metabolism was investigated in Sprague-Dawley rats. Four-week-old male rats were fed diets containing 0～ 0. 20% sesaminol. After 4 week-feeding period, serum and liver lipids levels were determined. We reported, for the first time, that dietary sesaminol significantly reduce(s) serum and hepatic lipids, especially triglyceride levels in a dose dependent manner ; this reduction appeared to be greater than those of a well-known other functional components. The mechanism responsible for the observed reduction in the concentration of triglyceride may be due to a reciprocal response in the enzyme activities involved in fatty acid synthesis and oxidation.

(1 results)