Analysis of the hyaluronan-dependent signaling in vertebrateheart formation

2012 Fiscal Year Final Research Report

• Project/Area Number: 22770204
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Cell biology
• Research Institution: National Institute of Advanced Industrial Science and Technology
• Principal Investigator: ITO Yuzuru 独立行政法人産業技術総合研究所, 幹細胞工学研究センター, 研究チーム長 (30500079)
• Project Period (FY): 2010 – 2012
• Keywords: 発生・分化 / マイクロアレイ / 糖鎖 / 再生医学 / シグナル伝達

Research Abstract

I identified many novel genes expected as factor belong to hyaluronan-dependent signaling pathway. 7 genes were detected in heart. 6 genes were detected in blood vessel. 4 genes were detected in liver. 12 genes were detected in blood cells. These three ti

Research Products

• [Journal Article] A lectin-based glycomic approach to identify characteristic features of Xenopus embryogenesis. (2013)
  • Author(s): Onuma Y, Tateno H, Tsuji S, Hirabayashi J, Ito Y, Asashima M
  • Journal Title: PLoS One Volume: 8 Pages: e56581
  • DOI: DOI:10.1371/journal.pone.0046630
  • Peer Reviewed
• [Journal Article] 発生学から見た再生医療 (2011)
  • Author(s): 浅島誠、 伊藤弓弦、栗崎晃
  • Journal Title: 再生 医療 Volume: 10(3) Pages: 17-33
  • URL: http://med.m-review.co.jp/magazine/detail1/J27_10_3_17-33.html
• [Journal Article] Claudin5 genes encoding tight junction proteins are required for Xenopus heart formation (2010)
  • Author(s): Yamagishi, M., Ito, Y., Ariizumi, T., Komazaki, S., Danno, H., Michiue, T., Asashima, M.
  • Journal Title: Dev. Growth Differ Volume: 52 Pages: 665-675
  • DOI: DOI:10.1111/j.1440-169X.2010.01204.x
  • Peer Reviewed
• [Presentation] Global gene expression analysis of Xenopus cells cultured in the International Space Station (KIBO). (2012)
  • Author(s): Yuzuru Ito
  • Organizer: 14th International Xenopus Conference
  • Place of Presentation: Hotel Belambra (Giens Peninsula, France)
  • Year and Date: 20120909-13
• [Presentation] 初期心臓形成に関与するヒアルロン酸経路の解析 (2012)
  • Author(s): 岩本 麻未
  • Organizer: 第11回産総研・産技連 LS-BT 合同研究発表会
  • Place of Presentation: 産総研(茨城)
  • Year and Date: 2012-01-31
• [Presentation] Challenge the establishment of new fundamental technology in the regenerative medicine (2010)
  • Author(s): Ito, Y.
  • Organizer: 2nd Symposium on Systems and Synthetic Biology (TriSys)
  • Place of Presentation: AIST (Tokyo)
  • Year and Date: 2010-10-04
• [Book] Mechanobiology During Vertebrate Organ Development, Mechanosensing Biology (2010)
  • Author(s): Asashima M, Michiue T, Ohnuma K, Nakajima Y , Ito Y
  • Total Pages: 11(39-49)
  • Publisher: Springer