2012 Fiscal Year Final Research Report
The evolution of coding triplet repeats in human genome
| Project/Area Number |
22770239
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Physical anthropology
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| Research Institution | The Graduate University for Advanced Studies |
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Principal Investigator |
GOJOBORI Jun 総合研究大学院大学, 先導科学研究科, 助教 (00506800)
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| Project Period (FY) |
2010 – 2012
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| Keywords | アミノ酸リピート / 不確定領域 |
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| Research Abstract |
It is proposed that triplet repeats in coding regions are more likely to form disordered region in protein structure. It is suggested that disordered regions evolve faster. In this study, I examine the relationship between the evolutionary rate and protein structure for triplet repeats in coding regions. I showed that the repeats in non-disordered region evolved faster than disordered region during primate evolution. Here I revealed primate specific evolution on coding triplet repeats.
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