2011 Fiscal Year Final Research Report
Molecular mechanisms of permeability transition revealed using yeast mitochondria
| Project/Area Number |
22790070
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | The University of Tokushima |
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Principal Investigator |
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| Research Collaborator |
SHINOHARA Yasuo 徳島大学, 疾患ゲノム研究センター, 教授 (60226157)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 細胞生物学 |
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| Research Abstract |
Mitochondrial permeability transition triggers subsequent steps of apoptosis. To understand the molecular mechanisms of permeability transition, we in this research accessed to identify the regulatory genes for permeability transition using yeast mitochondria. As a result, we revealed that possible regulatory genes involved in permeability transition in previous reports did not mainly regulate permeability transition.
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Research Products
(17 results)
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[Journal Article] S-15176 and its methylated derivative suppress the CsA-insensitive mitochondrial permeability transition and subsequent cytochrome c release induced by silver ion, and show weak protonophoric activity2011
Author(s)
Kawashima S, Yamamoto T, Horiuchi Y, Fujiwara K, Gouda S, Yoshimura Y, Yamamoto A, Inotani Y, Yamashita K, Kitamura S, Terada H, Kanematsu M, Shishido K, Shinohara Y
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Journal Title
Mol Cell Biochem
Volume: 358
Pages: 45-51
DOI
Peer Reviewed
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[Journal Article] Differential effects of cold exposure on gene expression profiles in white versus brown adipose tissue2011
Author(s)
Watanabe M, Yamamoto T, Yamamoto A, Obana E, Niiyama K, Hada T, Ooie T, Kataoka M, Hori T, Houchi H, Shinohara Y
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Journal Title
Appl Biochem Biotechnol
Volume: 165
Pages: 538-547
DOI
Peer Reviewed
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