2012 Fiscal Year Final Research Report
Development and mechanistic study of novel anti- Alzheimer's disease drugs with PKC-ε selective activation
| Project/Area Number |
22790120
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Drug development chemistry
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| Research Institution | Hyogo University of Health Sciences |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 医薬品化学 / PKC-ε / 認知症治療剤 / DCP-LA / 構造活性相関 / ターゲット探索 |
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| Research Abstract |
We have already synthetic route for the preparation of all of the four isomers of enantiomerically pure DCP-LA employing lipase-mediated resolution method, and found the most active stereoisomers. However, first synthetic route was difficult for gram-scale synthesis of optically active DCP-LA. In this research, we have developed synthetic route for gram-scale preparation of all of the four isomers of enantiomerically pure DCP-LA, and found the most active stereoisomers in vivo system. In addition, we found that novel free fatty acid derivative HUHS2002 activated α7 ACh receptor responces. Fuethemore, we identified some candidates of target protein of DCP-LA with affinity chromatography methods.
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