2011 Fiscal Year Final Research Report
Novel pathophysiological mechanisms involving the aberrant trafficking of sodium pump in human cancer cells
| Project/Area Number |
22790204
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General physiology
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| Research Institution | University of Toyama |
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Principal Investigator |
FUJII Takuto 富山大学, 大学院・医学薬学研究部(薬学), 助教 (50567980)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 癌 / ナトリウムポンプ / トラフィッキング / 原形質膜 / 小胞 |
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| Research Abstract |
Na+, K+-ATPaseα3-isoform(α3NaK) is abnormally expressed in various types of human cancer cells.α3NaK is not localized in plasma membrane, but in intracellular vesicles in which rab10 is present. In vitro and in vivo studies using human and mouse cancer cells showed thatα3NaK may be involved in the mechanisms of cancer cell survival and growth.
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