2012 Fiscal Year Final Research Report
The Dynamic mechanism of phagocytosis of apoptotic cells
| Project/Area Number |
22790210
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General physiology
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| Research Institution | Osaka University (2011-2012)
Kyoto University (2010) |
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Principal Investigator |
HANAYAMA Rikinari 大阪大学, 免疫学フロンティア研究センター, 特任准教授 (40403191)
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| Project Period (FY) |
2010 – 2012
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| Keywords | アポトーシス / マクロファージ / 貪食 |
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| Research Abstract |
Apoptotic cells are engulfed by macrophages by recognizing phosphatidylserine (PS). We found that Tim4 receptor on macrophages tethers apoptotic cells to macrophages by binding PS, and MFG-E8 secreted from macrophages binds to PS and stimulates the engulfment by binding to integrin on macrophages.
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