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2011 Fiscal Year Final Research Report

Roles of leukotriene receptor signaling in cell proliferation

Research Project

  • PDF
Project/Area Number 22790320
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Pathological medical chemistry
Research InstitutionKyushu University

Principal Investigator

SAEKI Kazuko  九州大学, 大学院・医学研究院, 助教 (00553273)

Project Period (FY) 2010 – 2011
Keywords生理活性脂質 / GPCR / 病態モデル
Research Abstract

BLT2 is a receptor for LTB_4 and 12-HHT and expressed on the epithelium of skin and intestine. To clarify the role of BLT2 in these tissues, the models of inflammatory colitis, tumorigenesis in the colon, and skin wound healing were performed. It was revealed that BLT2 suppresses inflammatory colitis and tumorigenesis in the colon and promotes skin wound healing.

  • Research Products

    (39 results)

All 2012 2011 2010 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (30 results) Remarks (1 results)

  • [Journal Article] A high-affinity monoclonal antibody against the FLAG tag useful for G-protein coupled receptor study2012

    • Author(s)
      Sasaki F, Okuno T, Saeki K, Liu M, Onohara N, Kato H, Shimizu T, Yokomizo T
    • Journal Title

      Anal Biochem

      Volume: 425(2) Pages: 157-165

    • DOI

      DOI:10.1016/j.ab.2012.03.014

    • Peer Reviewed
  • [Journal Article] IL-27 inhibits pathophysiological intraocular neovascularization due to laser burn2012

    • Author(s)
      Hasegawa E, Oshima Y, Takeda A, Saeki K, Yoshida H, Sonoda KH, Ishibashi T
    • Journal Title

      J Leukoc Biol

      Volume: 91(2) Pages: 267-273

    • DOI

      DOI: 10.1189/jlb.1110603

    • Peer Reviewed
  • [Journal Article] miR126 positively regulates mast cell proliferation and cytokine production through suppressing Spred12011

    • Author(s)
      shizaki T, Tamiya T, Taniguchi K, Morita R, Kato R, Okamoto F, Saeki K, Nomura M, Nojima Y, Yoshimura A
    • Journal Title

      Genes to Cells

      Volume: 16(7) Pages: 803-814

    • DOI

      DOI: 10.1111/j.1365-2443.2011.01529.x.

    • Peer Reviewed
  • [Journal Article] Raftlin is involved in the nucleocapture complex to induce poly(I : C)-mediated TLR3 activation2011

    • Author(s)
      Watanabe A, Tatematsu M, Saeki K, Shibata S, Shime H, Yoshimura A, Obuse C, Seya T, Matsumoto M
    • Journal Title

      J Biol Chem

      Volume: 286(12) Pages: 10702-10711

    • DOI

      DOI: 10.1074/jbc.M110.185793

    • Peer Reviewed
  • [Journal Article] Leukotriene B4 augments and restores Fc gamma Rs-dependent phagocytosis in macrophages2010

    • Author(s)
      Okamoto F, Saeki K, Sumimoto H, Yamasaki S, Yokomizo T
    • Journal Title

      J Biol Chem

      Volume: 285(52) Pages: 41113-41121

    • DOI

      DOI:10.1074/jbc.M110.175497

    • Peer Reviewed
  • [Journal Article] Protective role of the leukotriene B4 receptor BLT2 in murine inflammatory colitis2010

    • Author(s)
      Iizuka Y, Okuno T, Saeki K, Uozaki H, Okada S, Misaka T, Sato T, Toh H, Fukayama M, Takeda N, Kita Y, Shimizu T, Nakamura M, Yokomizo T
    • Journal Title

      FASEB J

      Volume: 24(12) Pages: 4678-4690

    • DOI

      DOI:10.1096/fj.10-165050

    • Peer Reviewed
  • [Journal Article] HB-EGF function in cardiac valve development requires interaction with heparan sulfate proteoglycans2010

    • Author(s)
      Iwamoto R, Mine N, Kawaguchi T, Minami S, Saeki K, Mekada E
    • Journal Title

      Development

      Volume: 137(13) Pages: 2205-2214

    • DOI

      DOI: 10.1242/dev.048926

    • Peer Reviewed
  • [Journal Article] Attenuated Th1 induction by dendritic cells from mice deficient in the leukotriene B4 receptor 12010

    • Author(s)
      Toda A, Terawaki K, Yamazaki S, Saeki K, Shimizu T, Yokomizo T
    • Journal Title

      Biochimie

      Volume: 92(6) Pages: 682-691

    • DOI

      DOI: 10.1016/j.biochi.2009.12.002

    • Peer Reviewed
  • [Presentation] BLT1 as a potential marker of mouse dendritic cell subset2012

    • Author(s)
      Koga T, Sasaki F, Saeki K, Okuno T, Yokomizo T
    • Organizer
      The 9th Global COE International Symposium & 8th Young Investigators Forum
    • Place of Presentation
      Fukuoka
    • Year and Date
      2012-01-21
  • [Presentation] Crucial role of the leukotriene B4 receptor 2, BLT2 in epidermal wound healing2011

    • Author(s)
      Liu M, Saeki K, Yokomizo T
    • Organizer
      The 10th Global COE International Symposium & 7th Young Investigators Forum
    • Place of Presentation
      Singapore
    • Year and Date
      2011-12-23
  • [Presentation] BLT1 as a potential marker of mouse dendritic cell subset2011

    • Author(s)
      Koga T, Sasaki F, Saeki K, Okuno T, Yokomizo T
    • Organizer
      The 10th Global COE International Symposium & 7th Young Investigators Forum
    • Place of Presentation
      Singapore
    • Year and Date
      2011-12-23
  • [Presentation] BLT1 は樹状細胞の新規マーカー分子となりうるか?2011

    • Author(s)
      古賀友紹, 佐伯和子, 佐々木文之, 奥野利明, 横溝岳彦
    • Organizer
      第8回東京呼吸器リサーチフォーラム
    • Place of Presentation
      東京
    • Year and Date
      2011-11-19
  • [Presentation] Two distinct leukotriene B4 receptors: BLT1 and BLT22011

    • Author(s)
      Yokomizo T, Liu M, Saeki K, Okuno T
    • Organizer
      The 10th JBS Biofrontier Symposium : New aspects of phospholipid biology and medicine
    • Place of Presentation
      Fukuoka
    • Year and Date
      2011-11-16
  • [Presentation] Leukotriene B4 augments and restores FcgRs-dependent phagocytosis in macrophages2011

    • Author(s)
      Saeki K, Okamoto F, Yokomizo T
    • Organizer
      The 10th JBS Biofrontier Symposium : New aspects of phospholipid biology and medicine
    • Place of Presentation
      Fukuoka
    • Year and Date
      2011-11-15
  • [Presentation] Expression of an LTB4 receptor BLT1 in M2 macrophages2011

    • Author(s)
      Sasaki F, Koga T, Saeki K, Okuno T, Yokomizo T
    • Organizer
      The 10th JBS Biofrontier Symposium : New aspects of phospholipid biology and medicine
    • Place of Presentation
      Fukuoka
    • Year and Date
      2011-11-15
  • [Presentation] BLT1 as a potential marker of mouse dendritic cell subsets2011

    • Author(s)
      Koga T, Sasaki F, Saeki K, Okuno T, Yokomizo T
    • Organizer
      The 10th JBS Biofrontier Symposium : New aspects of phospholipid biology and medicine
    • Place of Presentation
      Fukuoka
    • Year and Date
      2011-11-15
  • [Presentation] Improved immunoprecipitation method for epitope-tagged GPCRs2011

    • Author(s)
      Morisaki Y, Sasaki F, Aratake Y, Okuno T, Saeki K, Yokomizo T
    • Organizer
      The 10th JBS Biofrontier Symposium : New aspects of phospholipid biology and medicine
    • Place of Presentation
      Fukuoka
    • Year and Date
      2011-11-15
  • [Presentation] Crucial role of the leukotriene B4 receptor BLT2 in epidermal wound healing2011

    • Author(s)
      Liu M., 佐伯和子, 奥野利明, 横溝岳彦
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2011-09-24
  • [Presentation] 二つのロイコトリエンB4 受容体(BLT1, BLT2)のシグナルと病態生理機能2011

    • Author(s)
      佐伯和子, 劉〓, 岡元冬樹, 奥野利明, 横溝岳彦
    • Organizer
      第84回日本生化学会大会シンポジウム
    • Place of Presentation
      京都
    • Year and Date
      2011-09-23
  • [Presentation] GPCR の免疫沈降に有用な新規抗FLAG 抗体の樹立と本抗体を用いた新規GPCR 結合タンパク質の探索2011

    • Author(s)
      佐々木文之, 奥野利明, 佐伯和子, 横溝岳彦
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2011-09-22
  • [Presentation] Improved immunoprecipitation method for epitope-tagged GPCRs2011

    • Author(s)
      森崎雄一, 佐々木文之, 荒武良総, 奥野利明, 佐伯和子, 横溝岳彦
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2011-09-22
  • [Presentation] Crucial role of the 12-HHT receptor BLT2 in epidermal wound healin2011

    • Author(s)
      Liu M, Saeki K, Okuno T, Yokomizo T
    • Organizer
      第6回GCOR 理医連携リトリート
    • Place of Presentation
      阿蘇
    • Year and Date
      2011-08-05
  • [Presentation] M2 マクロファージにおけるBLT1の発現と機能解析2011

    • Author(s)
      佐々木文之、佐伯和子、奥野利明、横溝岳彦
    • Organizer
      第6回GCOR 理医連携リトリート
    • Place of Presentation
      阿蘇
    • Year and Date
      2011-08-05
  • [Presentation] BLT1 as a potential marker of mouse dendritic cell subsets2011

    • Author(s)
      Koga T, Sasaki F, Saeki K, Okuno T, Yokomizo T
    • Organizer
      第6回GCOR 理医連携リトリート
    • Place of Presentation
      阿蘇
    • Year and Date
      2011-08-05
  • [Presentation] Improved immunpricipitation methods. for epitope-tagged GPCRs2011

    • Author(s)
      Morisaki Y, Sasaki F, Aratake Y, Okuno T, Saeki K, Yokomizo T
    • Organizer
      第6回GCOR 理医連携リトリート
    • Place of Presentation
      阿蘇
    • Year and Date
      2011-08-05
  • [Presentation] Leukotriene B_4 augments and restores FcγRs-dependent phagocytosis in macrophages2011

    • Author(s)
      Saeki K, Okamoto F, Yamasaki S, Yokomizo T
    • Organizer
      Experimental Biology 2011 (ASBMB Annual Meeting)
    • Place of Presentation
      Washington, DC, USA
    • Year and Date
      2011-04-11
  • [Presentation] Crucial role of the leukotriene B4 receptor BLT2 in epidermal wound healing2011

    • Author(s)
      Liu M, Saeki K, Abe Y, Yokomizo T
    • Organizer
      Experimental Biology 2011 (ASBMB Annual Meeting)
    • Place of Presentation
      Washington, DC, USA
    • Year and Date
      2011-04-10
  • [Presentation] Generation of monoclonal antibodies specific for mouse leukotriene B4 receptor 1 and N-terminal flag sequence2011

    • Author(s)
      Sasaki F, Saeki K, Okuno T, Yokomizo T
    • Organizer
      Experimental Biology 2011 (ASBMB Annual Meeting)
    • Place of Presentation
      Washington, DC, USA
    • Year and Date
      2011-04-10
  • [Presentation] Roles of 12-HHT/LTB4 receptor, BLT2 in murine inflammatory colitis2011

    • Author(s)
      Okuno T, Izuka Y, Saeki K, Yokomizo T
    • Organizer
      Experimental Biology 2011(ASBMB Annual Meeting)
    • Place of Presentation
      Washington, DC, USA
    • Year and Date
      2011-04-10
  • [Presentation] Crucial role of the leukotriene B4 receptor 2, BLT2 in epidermal wound healing2011

    • Author(s)
      Liu M, Saeki K, Yokomizo T
    • Organizer
      6th G-COE Young Investigators Forum
    • Place of Presentation
      Bintan Island, Indonesia
    • Year and Date
      2011-02-12
  • [Presentation] Generation of monoclonal antibody for mouse leukotriene B4 receptor 12011

    • Author(s)
      Sasaki F, Saeki K, Okuno T, Yokomizo T
    • Organizer
      6th G-COE Young Investigators Forum
    • Place of Presentation
      Bintan Island, Indonesia
    • Year and Date
      2011-02-12
  • [Presentation] Crucial role of the leukotriene B4 receptor BLT2 in epidermal wound healing2010

    • Author(s)
      Liu M, Saeki K, Yokomizo T
    • Organizer
      The 83^<th> Annual Meeting of the Japanese Biochemical Society
    • Place of Presentation
      Kobe
    • Year and Date
      2010-12-08
  • [Presentation] マクロファージ貪食におけるロイコトリエンB4 受容体(BLT1)の機能解析2010

    • Author(s)
      岡元冬樹、佐伯和子、奥野利明、山崎晶、横溝岳彦
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-08
  • [Presentation] Generation of monoclonal antibody for mouse leukotriene B4 receptor 12010

    • Author(s)
      佐々木文之、佐伯和子、横溝岳彦
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-08
  • [Presentation] マウス炎症性腸炎における12-HHT/LTB4 受容体BLT2 の役割2010

    • Author(s)
      奥野利明、飯塚佳子、佐伯和子、清水孝雄、中村元直、横溝岳彦
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-08
  • [Presentation] 炎症性腸疾患モデルから明らかになった12-HHT/LTB4 受容体BLT2 の抗炎症作用2010

    • Author(s)
      奥野利明、飯塚佳子、佐伯和子、清水孝雄、中村元直、横溝岳彦
    • Organizer
      第7回東京リサーチフォーラム
    • Place of Presentation
      東京
    • Year and Date
      2010-11-06
  • [Presentation] マクロファージ貪食におけるロイコトリエンB4 受容体(BLT1)の機能解析2010

    • Author(s)
      岡元冬樹、佐伯和子、奥野利明、山崎晶、横溝岳彦
    • Organizer
      第5回GCOE 理医連携リトリート
    • Place of Presentation
      福岡
    • Year and Date
      2010-08-18
  • [Presentation] 抗マウスロイコトリエンB4 受容体モノクローナル抗体の作製とその有用性の評価2010

    • Author(s)
      佐々木文之、佐伯和子、奥野利明、横溝岳彦
    • Organizer
      第5回GCOE 理医連携リトリート
    • Place of Presentation
      福岡
    • Year and Date
      2010-08-18
  • [Remarks]

    • URL

      http://www.med.kyushu-u.ac.jp/biochem1/

URL: 

Published: 2015-03-12  

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