2011 Fiscal Year Final Research Report
Elucidation of mechanism of cardioprotective effect by wnt11 and development of therapeutic application
| Project/Area Number |
22790698
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | wnt11 / アデノ関連ウイルス-9(AAV9) / 心筋炎 / 炎症抑制 |
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| Research Abstract |
Wnt11 therapy using adeno-associated virus improved survival of mice with myocarditis by about 30%. We tried to clarify the mechanism to improve survival. We found wnt11 significantly suppressed the production of inflammatory cytokines from activated Raw cells which are cell line of macrophage. We showed wnt11 has therapeutic effect on virus-induced myocarditis.
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Research Products
(1 results)
