2011 Fiscal Year Final Research Report
The relation between the pattern of urine proteome and renal parameters
| Project/Area Number |
22790778
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Kidney internal medicine
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| Research Institution | Yamagata University |
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Principal Investigator |
IKEDA Ami 山形大学, 医学部, 助教 (50536985)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 尿プロテオーム / 慢性腎臓病 / 腎予後マーカー / 一般住民 |
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| Research Abstract |
To clarify the clinical utility of urine proteome in renal diseases, we investigate the relation between the pattern of urine proteome and renal parameters in health checkup participants and patients with renal diseases. The urine specimens of renal diseases showed the 0-8 peaks in proteome pattern and the number of proteome peak was increased along with the increase in urine protein excretion. The range of highest peak in proteome pattern was related with the renal histological changes. The 1-year decrease in estimated GFR (mL/min/1.73m^2) was larger in groups with 10-40k peakand 60-80k peak, compared with no peak group. The urine proteome pattern is related with renal parameters, and could be a useful renal index in clinical practice.
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