2011 Fiscal Year Final Research Report
Is a prion hypothesis the validity?: The real pathogen explored from the host innate immune systems
| Project/Area Number |
22790955
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Infectious disease medicine
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| Research Institution | Nagasaki University |
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Principal Investigator |
ISHIBASHI Daisuke 長崎大学, 大学院・医歯薬学総合研究科, 助教 (10432973)
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| Project Period (FY) |
2010 – 2011
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| Keywords | プリオン / 自然免疫 / IRF3 |
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| Research Abstract |
In this research assignment, we focused the innate immune system in host, and examined the relationship between prion infection and the system. As a result, we revealed that transcription factor IRF3 plays a key role in prion infection. Consequently, we considered that development of prevention and therapeutic agent against the prion disease which targeted the innate immune system would progress by this research project.
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Research Products
(13 results)
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[Journal Article] Direct evidence of generation and accumulation ofβ-sheet-rich prion protein in ScN2a cells de novo illuminated by human IgG1 antibody recognizingβ-form but notα-form of prion protein2012
Author(s)
Kubota T, Hamazoe Y, Hashiguchi S, Ishibashi D, Akasaka K, Nishida N, Katamine S, Sakaguchi S, Kuroki R, Nakashima T, Sugimura K.
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Journal Title
J Biol Chem
Volume: (In press)
Pages: Feb 22
Peer Reviewed
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[Journal Article] Ultrasensitive human prion detection in cerebrospinal fluid by real-time quaking-induced conversion2011
Author(s)
Atarashi R, Satoh K, Sano K, Fuse T, Yamaguchi N, Ishibashi D, Matsubara T, Nakagaki T, Yamanaka H, Shirabe S, Yamada M, Mizusawa H, Kitamoto T, Klug G, McGlade A, Collins SJ, Nishida N.
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Journal Title
Nat Med
Volume: 17(2)
Pages: 175-8
Peer Reviewed
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