2012 Fiscal Year Final Research Report
Pathological analysis of Pelizaeus-Merzbacher Disease using human iPSCs derived oligodendrocytes.
| Project/Area Number |
22791002
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatrics
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| Research Institution | Keio University |
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Principal Investigator |
NUMASAWA Yuko 慶應義塾大学, 医学部, 助教 (00571978)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 小児神経学 |
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| Research Abstract |
Pelizaeus-Merzbacher disease (PMD) is an X-linked leukodystrophy caused by mutations of Proteolipid protein 1 (PLP1) gene. We established patient specific induced pluripotent stem cells (iPSCs) from two PMD patients with missense point mutation, and diffe
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