2011 Fiscal Year Final Research Report
Analyzing the mechanism of graft-versus-host disease and contact hypersensitivity using bone-marrow transfer technique
| Project/Area Number |
22791067
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Dermatology
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| Research Institution | Kyoto University |
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Principal Investigator |
EGAWA Gyohei 京都大学, 医学研究科, 助教 (50511812)
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| Co-Investigator(Renkei-kenkyūsha) |
KABASHIMA Kenji 京都大学, 医学研究科, 准教授 (00362484)
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| Research Collaborator |
NATSUAKI Yohei 京都大学, 医学研究科, 研究員
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| Project Period (FY) |
2010 – 2011
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| Keywords | 樹状細胞 / 抗原提示 / 接触過敏反応 / 移植片対宿主反応 |
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| Research Abstract |
We evaluated the antigen presenting capacity of skin dendritic cell(DC) subset by subset-specific depletion using CD11c-DTR and Langerin-DTR mice in combination with bone marrow chimeric techniques. Depletion of Langerhans cells alone in the elicitation phase induced a prolonged contact hypersensitivity(CHS) response, whereas CHS response was almost diminished when both LCs and dermal DCs were depleted. We also developed new research model for graft-versus-host disease(GVHD), Involucrin-mOVA mice.
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