An investigation of early diagnosis of Alzheimer's disease. Study with subjective cognitive impairment-

2011 Fiscal Year Final Research Report

• Project/Area Number: 22791138
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Psychiatric science
• Research Institution: Nara Medical University
• Principal Investigator: KIUCHI Kuniaki 奈良県立医科大学, 医学部, 助教 (20398449)
• Project Period (FY): 2010 – 2011
• Keywords: 拡散テンソルトラクトグラフィー / アルツハイマー病 / 主観的認知障害 / 拡散テンソル画像

Research Abstract

Amnestic mild cognitive impairment(aMCI) is considered to be a transitional stage in Alzheimer's disease(AD). Several studies using diffusion tensor imaging(DTI) showed abnormalities of the white matter in aMCI patients. Subjective cognitive impairment(SCI) is thought to be a preclinical stage in the course of AD that may precede aMCI. In this DTI study, we investigated on SCI subjects(n=22) by comparing age matched early AD(n=27), aMCI(n=28) and normal control(NC)(n=28). SCI subjects had lower FA region in the posterior cingulum than NC. This finding may represent early subtle change in the course of dementia.