2011 Fiscal Year Final Research Report
Investigation of the mechanism of metabotropic glutamate receptor 5 activity which protein related to psychiatric disorder.
| Project/Area Number |
22791149
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | Kurume University |
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Principal Investigator |
UEMATSU Ken 久留米大学, 医学部, 助教 (60441672)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 精神薬理学 / 分子生物学 / 細胞内情報伝達 / 蛋白リン酸化修飾 / 細胞内カルシウム動態 |
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| Research Abstract |
In this research, we discovered new phosphorylation site of mGluR5, which phosphorylated by PKA and the site is serine 870 of mGluR5. Methods of this study, we generate mGluR5 C-teerminal peptie for in vitro phosphorylation assay by protein kinase A and【γ-32P】ATP. Compared with wild and mutant mGluR5 C-terminal peptide, mutant inhibited to gain【γ-32P】labeled isotope. Now we set up the experiment of the function by this mGluR5 phosphorylation.
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