2011 Fiscal Year Final Research Report
Relations between hyaluronan metabolism and CD44 in lung cancer.
| Project/Area Number |
22791307
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Thoracic surgery
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 肺癌 / ヒアルロン酸 / CD44 |
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| Research Abstract |
We studied relations between immunoreactivities for CD44std, CD44v6, and galectin-9 in lung cancer tissues and their histological types, degree of differenciation, pathological staging, and prognosis. Majority of squamous cell carcinoma was immunoreactive of CD44std and CD44v6, while it was less immunoreactive for galectin-9. In contrast, adenocarcinoma was much less immunoreactive for CD44std and CD44v6 than squamous cell carcinoma. However, it was mostly immunoreactive for galectin-9. Our results suggested that squamous cell carcinoma had a different behavior to extracellular matrix such as hyaluronan from adenocarcinoma, and also indicated a possible negative regulation between CD44 and galectin-9 in lung cancer tissues.
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Research Products
(8 results)
