2012 Fiscal Year Final Research Report
The clinical value of Circulating Tumor Cells (CTC) in patients undergoing pulmonary metastasectomy for metastatic colorectal cancer
| Project/Area Number |
22791326
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Thoracic surgery
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 循環血液中腫瘍細胞(CTC) / 結腸直腸癌肺転移 |
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| Research Abstract |
In this context, we conducted a prospective study to evaluate whether preoperative Circulating tumor cells (CTC)-count predicts survival after pulmonary metastasectomy in patients with metastatic colorectal cancer. Preoperative CTC-count was quantitatively evaluated with a 7.5-mL of peripheral blood sample using CellSearchTM system. Based on previously published criteria, patients were divided into favorable group and unfavorable group according to preoperative CTC-count of < 3 or ≧ 3 /7.5mL, respectively. The estimated 5-year survival rates were 80.4% in favorable group (n=50) and 0% in unfavorable group (n=2). There was a significant difference in postoperative survival between favorable and unfavorable groups (p<0.001). An elevated preoperative CTC-count (CTC≧3 /7.5mL) is an independent poor prognostic factor in patients with metastatic colorectal cancer. Pulmonary metastasectomy in such cases should be reconsidered even when they meet conventional surgical criteria.
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