2011 Fiscal Year Final Research Report
TRPV4 ; pathogenesis and a new therapeutic target of osteoarthritis
| Project/Area Number |
22791376
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kyoto University |
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Principal Investigator |
YAMAMOTO Koji 京都大学, 医学研究科, 助教 (70536565)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 変形性関節症 / メカニカルストレス / 遺伝子改変マウス / TRPV4 / Sox9 |
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| Research Abstract |
In vivo observation of the Sox9 expression using Sox9-EGFP mice revealed that the Sox9 on the articular surface was increased temporally through TRPV4, which is one of the mechano-gated channels in chondrocytes, at the initial stage of osteoarthritis(OA). In addition, TRPV4 knock-out mice exhibited severer degradation of cartilage in the experimental OA model than wild-type mice. Furthermore, a selective agonist for TRPV4, GSK1016790A, induced the temporal expression of Sox9 in chondrocytes and was found to have a potential to inhibit the progression of OA.
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[Presentation] TRPV4はSox9の発現を介して変形性関節症の発症を抑制する2012
Author(s)
山本浩司, 村尾浩樹, 金永優, 武井大輔, 村尾浩樹, 末吉達也, 塚中真佐子, 水野敦子, 鈴木誠, 中村孝志, 秋山治彦
Organizer
第25回日本骨代謝学会学術集会
Place of Presentation
愛知(シンポジウム)
Year and Date
2012-03-09
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