2012 Fiscal Year Final Research Report
Study for the mechanism of LH and FSH synthesis and secrition
| Project/Area Number |
22791533
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Shimane University |
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Principal Investigator |
ORIDE Aki 島根大学, 医学部, 助教 (00423278)
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| Co-Investigator(Renkei-kenkyūsha) |
MIJIDDORJ Tselmeg 島根大学, 医学部, 大学院生
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| Project Period (FY) |
2010 – 2012
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| Keywords | 生殖医学 / 下垂体 / ゴナドトロピン |
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| Research Abstract |
Gonadotropins are synthesized and secreted, which is under GnRH regulation. GnRH pulse frequency determines specific gonadotropin subunit gene expression. In pituitary gonadotrophs, GnRH induces expression of the Extracellular signal-regulated kinase(ERK) dephosphorylating enzyme, MAP kinase phosphatase 1 (MKP1). MKP-1 is specifically expressed following high-frequency GnRH pulses and that this effect may participate in the differential regulation of gonadotropin subunit expression. In addition to hypothalamic GnRH, pituitary adenylate cyclase - activating polypeptide (PACAP) also regulates gonadotropin gene expression. High-frequency PACAP pulse preferentially increased Lhb, whereas low-frequency PACAP pulses specifically increased Fshb. It suggest that PACAP is involved in the differential regulation of gonadotropin subunit gene expression.
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