2011 Fiscal Year Final Research Report
Novel regulatory mechanism for Exfoliative toxin in S. aureus
| Project/Area Number |
22791769
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
KATO Fuminori 広島大学, 大学院・医歯薬学総合研究科, 助教 (70452589)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 黄色ブドウ球菌 / 病原性 / 遺伝子発現 / 転写調節因子 |
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| Research Abstract |
During the search for a regulatory mechanism of exfoliative toxin in Staphylococcus aureus, I found two novel transcriptional regulators and designated it SptA and SptB. This study suggest that the SptA globally regulates various pathogenic factors by suppressing the expression of RNAIII that is most important key factor for a production of pathogenic factors in S. aureus. On the other hand, SptB represses the expression of exfoliative toxin by directly binding to the internal region of exfoliative toxin gene. These results propose a novel regulatory mechanism for the production of staphylococcal pathogenic factors.
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