2011 Fiscal Year Final Research Report
The development of biomimetic periodontal regenerative therapy by layered application of various growth factors and TCP-based materials
| Project/Area Number |
22791931
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Kagoshima University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 歯周組織再生療法 / 細胞成長因子 / EMD / bFGF / リン酸三カルシウム / CMキチン / 1壁性骨欠損 |
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| Research Abstract |
This study evaluated the effects of enamel matrix derivative(EMD) and/or basic fibroblast growth factor(bFGF) with β-tricalcium phosphate(β-TCP) on periodontal healing in intrabony defects in dogs. One-wall intrabony defects created in dogs were treated with β-TCP alone(TCP), EMD with β-TCP(EMD/TCP), bFGF with β-TCP(bFGF/TCP), and their combination(EMD/bFGF/TCP). The amount of new bone formation was not significant for any group. EMD/bFGF/TCP group induced significantly greater new cementum formation than TCP and bFGF/TCP groups, and formed, although not significantly, more new cementum than EMD/TCP group. These findings indicate that EMD/bFGF/TCP treatment is effective for cementum regeneration.
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