2011 Fiscal Year Final Research Report
Histological examination of bone regeneration induced by biomaterials mingled with mesenchymal stem cells
| Project/Area Number |
22791962
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Niigata University |
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Principal Investigator |
KOJIMA Taku 新潟大学, 医歯学系, 助教 (90515777)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 骨再生 / バイオマテリアル / 間葉系幹細胞 / 骨芽細胞 / 破骨細胞 / 骨細胞 / 骨質 |
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| Research Abstract |
We examined bone regeneration induce by our cell-delivery system, a porous beta-TCP block mingled with bone marrow stromal cells, in order to clarify histological events during the bone regeneration in this model. Bone marrow stromal cells obtained from the femora were induced into osteoblast-like cells, and then, seeded on a porous beta-TCP blocks. Beta-TCP blocks without the stromal cells were used as a control. The blocks were implanted in the rat calvariae and examined histologically. In the differentiated group, new bone was observed in the periphery of beta-TCP blocks, and then, it extended to the center of the beta-TCP blocks. In the control group, only a little new bone was observed in the bottom of the beta-TCP blocks. Thus, these results suggest that differentiated bone marrow stromal cells/beta-TCP composites have high osteogenic potential.
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[Presentation] Histological examination on bone regeneration induced by a porous beta-TCP block mingled with bone marrow stromal cells2011
Author(s)
Kojima T, Ono Y, Suzuki A, Sakagami N, Yoshizawa M, Hasegawa T, Amizuka N, Oda K, Maeda T, Saito C
Organizer
International Bone-Tissue-Engineering Congress, Convention Center CC
Place of Presentation
Hannover, Germany
Year and Date
20111012-15
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