2011 Fiscal Year Final Research Report
The role of the anti-apoptotic effect of angiogenin in vascular homeostasis
| Project/Area Number |
22791978
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
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| Research Collaborator |
HU Guo-fu Tufts大学, 教授
KODAMA Shinichi 岡山大学, 大学院, 大学院生
SHIBATA Akane 岡山大学, 大学院, 大学院生
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| Project Period (FY) |
2010 – 2011
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| Keywords | 口腔外科学一般 / 血管新生 |
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| Research Abstract |
To determine the physiological function of angiogenin(ANG), by making ANG gene inoperative, ANG knockout(KO) mice were created. Vascular endothelial(VE) cells were isolated from liver from wild type and KO mice, respectively. The growth of VE cells from KO mice(KOVE cells) was more suppressed than the one of VE cells from wild type mice. In serum-starved condition, KOVE cells were sensitive to stress and induced to apoptosis. ANG was found to be anti-apoptotic. Angiogenesis was suppressed in KO mice. Therefore, we shed light on the role of the anti-apoptotic effect of ANG in vascular homeostasis and angiogenesis.
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