2011 Fiscal Year Final Research Report
ClarifyingtheunderIyingmeGhanismsofschizophreniaviaoxidativestressinthebrain
| Project/Area Number |
22800048
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Kyushu University |
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Principal Investigator |
TAKAHIROA. Kato 九州大学, 先端融合医療レドックスナビ研究拠点, 特任助教 (70546465)
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| Project Period (FY) |
2010 – 2011
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| Keywords | ミクログリア / 統合失調症 / 炎症免疫 / 酸化ストレス |
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| Research Abstract |
Altered antioxidant status has been implicated in schizophrenia. Microglia, major sources of free radicals such as superoxide(. 02-), play crucial roles in various brain pathologies. Antioxidative effects of antipsychotics via modulating microglial superoxide generation have never been reported. Therefore, we herein investigated the effects of antipsychotics on the" 02 generation from phorbol-myristate-acetate(PMA)-stimulated rodent microglia by the electron spin resonance(ESR) spectroscopy and also examined the intracellular mechanism by intracellular Ca2+ imaging and immunostaining. Neuronal damage induced by microglial activation was also investigated by the co-culture experiment.
Our results imply that aripiprazole may have psychotropic effects by reducing the microglial oxidative reactions and following neuronal reactions, which puts forward a novel therapeutic hypothesis in schizophrenia research.
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[Journal Article] Aripiprazole inhibits superoxide generation from phorbolmyristateacetate(PMA) stimulated microglia in vitro : implication forantioxidative psychotropic actions via microglia2011
Author(s)
Kate TA, Monji A, Yasukawa K, Mizoguchi Y, Horikawa H, Seki Y, Hashioka S, Hah YH, Kasai M, Sonoda N, Hirata E, Maeda Y, Inoguchi T, Utsumi H, Kanba S
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Journal Title
Schizophrenia Research
Volume: 129(2-3)
Pages: 172-182
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[Journal Article] Introducing the Concept of Modern Depression in Japan ; an International Case Vignette Survey2011
Author(s)
Kato TA, Shinfuku N, Fujisawa D, Tate no M, Ishida T, Akiyama T, Sartorius N, Tee AR, Choi TY, Wand APF, Balhara YPS, Chang JPC, Chang RYF, Shadloo B, Ahmed HU, Lerthattasilp T, UmeneNakano W, Horikawa H, Matsumoto R, Kuga H, Tanaka M, Kanba S
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Journal Title
Journal of Affective Disorders
Volume: 135(1-3)
Pages: 66-76
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[Journal Article] mpact of biopsychosocial factors on psychiatric training in Japan and overseas : Are psychiatrists oriented to mind, brain, or sociocultural issues2010
Author(s)
Kato TA, Tate no M, Nakano Y, Balhara YPS, Tee AR, Fujisawa D, Sasaki R, Ishida 1, Kanba S
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Journal Title
Psychiatry and Clinical Neurosciences
Volume: 64(5)
Pages: 520-530
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[Journal Article] Inhibitory effects of SSRIs on IFN y induced microglial activation through the regulation of intracelluar calcium2010
Author(s)
Horikawa H, Kate TA, Mizoguchi Y, Monji A, Seki I, Gotoh L, Ohkuri I, Yonaha M, Ueda T, Hashioka S, Kanba S
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Journal Title
Prog Neuropsychopharmacol Biol Psychiatry
Volume: 34
Pages: 1306-1316
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[Journal Article] Does the' hikikomori' syndrome of social withdrawal exist outside Japan? A preliminary international investigation
Author(s)
Kato TA, Tate no M, Shinfuku N, Fujisawa D, Tee AR, Sartorius N, Akiyama T, Ishida T, Choi TV, Balhara YPS, Matsumoto R, UmeneNakano W, Fu j imura Y, Wand A, Chang JPC, Chang RYF, Shadloo B, Ahmed HU, Lerthattasilp T, Kanba S
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Journal Title
Social Psychiatry and Psychiatric Epidemiology
Volume: (in press)
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[Presentation] Aripiprazole inhibits superoxide generation from phorbolmyristateacetate(PMA) stimulated microglia in vitro2011
Author(s)
Kato TA, Monji A, Yasukawa K, Mizoguchi Y, Horikawa H, Seki Y, Hashioka S, Kasai M, Sonoda N, Hirata E, Maeda Y, Inoguchi T, Utsumi H, Kanba S
Organizer
16th JSPS Coreto-Core Seminar Winter School in Fukuoka
Place of Presentation
Lake Side Hotel Hisayama, Fukuoka
Year and Date
2011-01-08
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[Presentation] Antioxidative effect of aripiprazole, a novel unique antipsychotic, via inhibiting superoxide generation from PMA-stimulated microglia2010
Author(s)
Kate T, Monji A, Yasukawa K, MizoguchiY, Horikawa H, Seki Y, Yonaha M, Hashioka S, Han YH, Utsumi H, Kanba S
Place of Presentation
Hong Kong
Year and Date
2010-06-07
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[Remarks] 九州大学精神科ホームページ
