2012 Fiscal Year Final Research Report
Mechanism of itchiness adjusting by estrogen
| Project/Area Number |
22800053
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Neuroscience in general
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
TAKANAMI Keiko 京都府立医科大学, 解剖学・生体構造科学, プロジェクト研究員 (70578830)
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| Project Period (FY) |
2010 – 2012
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| Keywords | エストロゲン / 痒み / 掻破行動解析 / 起痒物質 |
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| Research Abstract |
Estrogens are originally identified as the primary sex steroid hormone in females regulating reproductive function and sexual behavior. It has long been suggested that estroge ns also have effects on the somatosensory system. It is generally and clinically well known that specific itch sensation is increased during the periods when circulating sex steroid hormone levels were dramatically changed such as pregnancy and climacterium. However, little is known whether itch threshold is related to estrogen level. In this study, we investigated the estrogen effects on itch sensation using behavioral pharmacological and histological analyses. Our results suggest that itch sensation is regulated by the circulating estrogen level in female rats, and raise the possibility that estrogens may regulate itch sensation by changes in CGRP expression in somatosensory system.
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[Presentation] Distribution of gastrin-releasing peptide in the trigeminal sensory system.2013
Author(s)
K Takanami, H Sakamoto, K-I Matsuda, KSatoh, K Inoue, S Yamada, T Tanida, T Oti, T Sakamoto, M Kawata.
Organizer
The 36th Annual Meeting of the Japan Neuroscience Society.
Place of Presentation
Kyoto international conference center, Kyoto, Japan
Year and Date
20130620-23
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