2023 Fiscal Year Annual Research Report
Mechanism of malaria-induced disruption of hematopoietic stem cell niche in the bone marrow
| Project/Area Number |
22K15448
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| Research Institution | The University of Tokyo |
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Principal Investigator |
LEE MICHELLE 東京大学, 医科学研究所, 特任助教 (10821423)
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| Project Period (FY) |
2022-04-01 – 2024-03-31
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| Keywords | lymphopoiesis / hematopoiesis / bone marrow niche / B cell |
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| Outline of Annual Research Achievements |
Stresses from infection and inflammation can alter or damage the hematopoietic stem cell (HSC) niches in the bone marrow. CXCL12-abundant reticular (CAR) cells surrounding the sinusoids are the major cellular component of perivascular HSC niches, that are in close contact with HSC and B cell progenitors to support HSC maintenance and lymphopoiesis. We found that malaria infection enhances hematopoiesis but causes an imbalance in the differentiation potential of multipotent progenitor cells. We found that malaria alters CAR cell population and suppresses B lymphopoiesis, as well as the retention of long-lived plasma cells in the bone marrow. This study suggests that malaria has an impact on B cell immunity.
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