Role of fluctuation in regulating the elastic-plastic property of tissues during organogenesis

2023 Fiscal Year Final Research Report

• Project/Area Number: 22K18749
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Review Section: Medium-sized Section 18:Mechanics of materials, production engineering, design engineering, and related fields
• Research Institution: Kanazawa University
• Principal Investigator: Okuda Satoru 金沢大学, ナノ生命科学研究所, 准教授 (80707836)
• Project Period (FY): 2022-06-30 – 2024-03-31
• Keywords: 生体力学

Outline of Final Research Achievements

To elucidate the adaptive regulatory mechanism of tissue elastoplasticity and the role of internal structural fluctuations in organogenesis, we have worked on multi-scale mathematical modeling to analyze the three-dimensional dynamics of cells from the cytoskeleton. In particular, in order to analyze long-term multicellular dynamics, we have developed a mathematical model of non-conservative fluid membranes to describe the non-equilibrium dynamics of cell membranes composed of lipids, cytoskeleton, and related molecules. Numerical simulations using this mathematical model enables us to predict the active three-dimensional mechanical dynamics of multicellular systems.

Free Research Field

生体力学

Academic Significance and Societal Importance of the Research Achievements

長時間スケールにおける多細胞の三次元力学動態に関する理解は，胚発生，がん進展，創傷治癒など，幅広い生命現象に関わる根本的な課題の一つである．特に，器官形成における組織弾塑性の適応性は，多細胞の適応的な振る舞いを決定する重要な因子である．本研究では提案した新規の数理モデルは，このような多細胞の三次元力学動態を予測することを可能にし，幅広い生命現象に共通する原理的な理解に繋がると期待される．