2023 Fiscal Year Final Research Report

Investigation of dynamics and function of supersulfide in skeletal muscle

Research Project

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Project/Area Number	22K19718
Research Category	Grant-in-Aid for Challenging Research (Exploratory)
Allocation Type	Multi-year Fund
Review Section	Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
Research Institution	Kyoto Prefectural University
Principal Investigator	Aoi Wataru 京都府立大学, 生命環境科学研究科, 准教授 (60405272)
Co-Investigator(Kenkyū-buntansha)	佐久間邦弘東京工業大学, リベラルアーツ研究教育院, 教授 (60291176)
Project Period (FY)	2022-06-30 – 2024-03-31
Keywords	骨格筋 / 硫黄代謝 / 抗酸化システム / 運動 / 不活動
Outline of Final Research Achievements	The purpose of this study was to investigate metabolic changes and function of sulfide compounds in skeletal muscle using animal models. We observed that exercise, muscle inactivity, and high-fat diet altered sulfur metabolism and supersulfide contents in skeletal muscle. In addition, administration of a supersulfide donor suppressed muscle atrophy and proteolytic signaling activity induced by inactivity. These results suggest the involvement of supersulfide in the maintenance and improvement of skeletal muscle function.
Free Research Field	スポーツ生化学
Academic Significance and Societal Importance of the Research Achievements	本研究により，骨格筋の硫黄代謝および超硫黄分子が運動・身体活動による筋機能の変化に関与すること，超硫黄分子量を制御することが不活動による筋萎縮の抑制につながることを示した。骨格筋のエネルギー産生や肥大・萎縮を調節するシグナル活性に硫黄代謝が関与することを踏まえ，筋機能の新しい調節機構を開拓した。