Development of precision mechanotherapy using functional antibody compounds

2024 Fiscal Year Final Research Report

• Project/Area Number: 22K19923
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Review Section: Medium-sized Section 90:Biomedical engineering and related fields
• Research Institution: Jikei University School of Medicine
• Principal Investigator: Makoto Mitsunaga 東京慈恵会医科大学, 医学部, 講師 (40433990)
• Project Period (FY): 2022-06-30 – 2024-03-31
• Keywords: 抗体療法 / がん / 分子標的薬 / 近赤外線 / メカノセラピー

Outline of Final Research Achievements

Near-infrared photoimmunotherapy (NIR-PIT) is a new cancer treatment that involves the use of a photosensitizing antibody compound and irradiation with NIR light. Although NIR light is a relatively harmless form of electromagnetic radiation to the human body, it is known to have limitations such as attenuation in deep tissues. In this research project, we aimed to develop a molecularly targeted and selective therapy using ultrasound, a biologically harmless sound wave that experiences less attenuation in deep tissues. We also conducted a comparative study to evaluate the efficacy of this approach against the existing NIR-PIT.

Free Research Field

分子イメージング

Academic Significance and Societal Importance of the Research Achievements

ある種の光感受性物質は超音波感受性を持ち合わせる報告があるが、今回の検討で用いた光感受性抗体化合物には近赤外光免疫療法と同等の分子標的選択的・細胞選択的な超音波感受性を誘導し得なかった。抗体化合物の改良や光感受性物質の検討により本技術の有用性が見いだせる可能性があり、今後の更なる検討が望まれる。