Regulation of intestinal microenvironment networks by polyamine nanoparticles and its application to the treatment of inflammatory bowel disease

2023 Fiscal Year Final Research Report

• Project/Area Number: 22K19947
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Review Section: Medium-sized Section 90:Biomedical engineering and related fields
• Research Institution: National Institute for Materials Science
• Principal Investigator: NISHIGUCHI Akihiro 国立研究開発法人物質・材料研究機構, 高分子・バイオ材料研究センター, 主幹研究員 (10784944)
• Project Period (FY): 2022-06-30 – 2024-03-31
• Keywords: ポリアミン / 免疫制御 / 炎症性疾患 / ナノ粒子 / 生体適合性

Outline of Final Research Achievements

Inflammatory bowel diseases including ulcerative colitis and Crohn's disease are intractable autoimmune diseases causing diarrhea and bloody stools due to abnormal enhancement of intestinal immunity. Conventional drug therapies have systemic side effects. We aimed to develop polyamine nanoparticles that regulate the intestinal microenvironmental networks and apply them to the treatment of inflammatory bowel disease. Polyamine nanoparticles composed of polyamine and hyaluronic acid with anti-inflammatory functions were developed. The relationship between molecular structure and ROS scavenging function was clarified to develop nanoparticles that control the intestinal microenvironmental networks.

Free Research Field

生体材料学、高分子化学

Academic Significance and Societal Importance of the Research Achievements

本研究では、潰瘍性大腸炎の治療薬として経口投与可能な抗炎症性ポリアミンナノ粒子を開発した。高い生体適合性と活性酸素消去活性を持つポリアミンをベースとしたナノメディンは、炎症性疾患の治療のための抗炎症薬として有用であると期待される。