2023 Fiscal Year Annual Research Report
Mathematical model for quantitatively analysis the pathophysiological characteristics of mouse photoreceptor cell
| Project/Area Number |
22K20514
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| Research Institution | Ritsumeikan University |
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Principal Investigator |
Muangkram Yuttamol 立命館大学, 立命館グローバル・イノベーション研究機構(BKC), 研究員 (90962473)
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| Project Period (FY) |
2022-08-31 – 2024-03-31
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| Keywords | ion channels / ion homeostasis / ionic current model / simulation model / mathematical model / photoreceptors / mouse retina |
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| Outline of Annual Research Achievements |
We have developed an innovative mathematical model of mouse photoreceptors that quantitatively describe the electrophysiological characteristics of ionic current dynamics and alterations in intracellular ion concentrations across varying light intensities. This model provides a robust quantitative framework for elucidating the substantial reduction in energy expenditure associated with increased light intensity, and for evaluating the energy supply from both anaerobic and aerobic glycolysis pathways. We have identified that further evidence is needed to determine whether alternative energy sources, such as lipid acids, are utilized in photoreceptors. Our research findings have been presented at domestic annual conferences, including JSMBE, Kinki PS, and PSJ, as well as internationally at conferences, including EMBC2023, and FAOPS2023. We have received extensive feedback and valuable suggestions for enhancing our model for publication. Additionally, our study has been successfully published in Scientific Reports in August. The study holds significant promise for advancing our understanding of photoreceptor energy metabolisms, which play a crucial role in various retinal diseases. Our future efforts will focus on further exploring the intricates of retinal dynamics, aiming to generate insights that can guide the development of novel therapeutic approaches for retinal diseases.
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