2023 Fiscal Year Annual Research Report
Development of Indigo Derivatives as Functional Molecules with Novel Photochemical Properties
| Project/Area Number |
22K20522
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| Research Institution | Hokkaido University |
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Principal Investigator |
HUANG CHUNG・YANG 北海道大学, 化学反応創成研究拠点, 准教授 (90956153)
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| Project Period (FY) |
2022-08-31 – 2024-03-31
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| Keywords | indigo / photochemistry / organic synthesis / metal catalysis / data science |
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| Outline of Annual Research Achievements |
During this FY, we completed the project of building indigo red-light photoswitches by copper-catalyzed N-arylation. Computation and experimental studies suggest that the exclusive selectivity for mono-N-arylation originates from a bimetallic Cu-indigo intermediate. Furthermore, we developed a workflow for correlating the structures of N-aryl substituents with the thermal half-lives of indigo photoswitches through multivariate linear regression. Finally, preliminary studies with a new molecular design have allowed to conjugate biomolecules with indigos, which showed red-light induced photoswitching. This work has been submitted for publication and is currently under review.
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