Elucidation of the role of the microbial signal molecules produced by nematode symbionts and its industrial applications

2023 Fiscal Year Final Research Report

• Project/Area Number: 22K20569
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0601:Agricultural chemistry and related fields
• Research Institution: Shinshu University
• Principal Investigator: Imai Yu 信州大学, 先鋭領域融合研究群バイオメディカル研究所, 助教(特定雇用) (20964042)
• Project Period (FY): 2022-08-31 – 2024-03-31
• Keywords: 線虫共生微生物 / シグナル分子

Outline of Final Research Achievements

It is known that microbes interact each other through signal molecules. In this study, we explored signal molecules from nematode symbionts that affect the phenotype of other bacteria, such as secondary metabolites production or cell development. We discovered compounds that suppress the pigmented antibiotic actinorhodin production in Streptomyces coelicolor A3(2) from culture of several Xenorhabdus strains, including Xenorhabdus szentirmaii DSM 16338. Subsequently, we successfully isolated two compounds from culture of X. szentirmaii DSM 16338 that inhibit actinorhodin production in S. coelicolor A3(2).

Free Research Field

応用微生物学

Academic Significance and Societal Importance of the Research Achievements

本研究では, これまでに放線菌の抗生物質生産を調節する微生物シグナル分子を発見することに成功している。今後, 本研究から様々なシグナル分子を発見し, それらを有効活用することができれば, 微生物を利用した物質生産 (抗生物質など) の効率化につなげることが期待できるなど, 産業分野における波及効果は大きい。