2015 Fiscal Year Annual Research Report
Immunological crosstalk between nasal and reproductive mucosal tissue
| Project/Area Number |
23229004
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| Research Institution | The University of Tokyo |
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Principal Investigator |
清野 宏 東京大学, 医科学研究所, 教授 (10271032)
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| Project Period (FY) |
2011-04-01 – 2016-03-31
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| Keywords | 粘膜免疫 / 生殖免疫 / 性感染症 / ワクチン / ケモカイン |
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| Outline of Annual Research Achievements |
In this study, we focused on the role of specific chemokine interaction in manifesting antigen-specific immune cell migration from nasal mucosa to genital mucosa which is necessary to achieve effective immune responses in genital tract against sexually transmitted infection. The current data showed that nasal immunization with HSV-2 TK- could induce the upregulation of chemokine receptor expression in CD4+ T cells in the antigen priming sites (e.g., CLNs) and vagina tissue. Expressions of ligands of the receptor expressions were all upregulated in vaginal tissue in stromal cells of vaginal tissue after nasal immunization. Furthermore, loss of the receptor, also impairs the migration of nasally primed antigen-specific effector cells from nasal mucosa to the vagina. These results indicate that the novel chemokine interaction is required for the migration and retention of nasally-primed Ag-specific tissue memory effector cells in vagina and further protection of the female reproductive tract against HSV-2 virus. The results generated through this study provide a means to effectively induce and modulate antigen-specific immune responses at the female genital mucosa through the novel chemokine pathway and contribute to the design of nasal vaccines for sexually transmitted diseases (e.g., HSV-2).
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| Research Progress Status |
27年度が最終年度であるため、記入しない。
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| Strategy for Future Research Activity |
27年度が最終年度であるため、記入しない。
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Research Products
(37 results)
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[Journal Article] Critical role of TSLP-responsive mucosal DCs for the induction of nasal antigen-specific IgA response. Mucosal Immunol.2017
Author(s)
Joo,S., Fukuyama, Y., Park,E-J., Yuki, Y., Kurashima, Y., Ziegler, S.F. and Kiyono,H.
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Journal Title
Mucosal Immunology
Volume: -
Pages: -
DOI
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Critical role of intestinal interleukin-4 modulating regulatory T Cells for desensitization, tolerance, and inflammation of food allergy.2017
Author(s)
Nakajima-Adachi, H., Shibahara, K., Fujimura, Y., Takeyama, J., Hiraide, E., Kikuchi, A., Murakami, H., Hosono, A., Nochi, T., Wakatsuki, Y., Shimojo, N., Kaminogawa, S., Sato, R., Kiyono, H. and Hachimura, S.
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Journal Title
PLoS One
Volume: 12
Pages: -
DOI
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Seed Metabolome analysis of a transgenic rice line expressing cholera toxin B-subunit.2017
Author(s)
Ogawa, T., Kashima, K., Yuki, Y., Mejima, M., Kurokawa, S., Okazawa, A., Kiyono, H. and Ohta, D.
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Journal Title
Science Reports
Volume: -
Pages: -
DOI
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Impaired airway mucociliary function reduces antigen-specific IgA immune response to immunization with a claudin-4-targeting nasal vaccine in mice.2017
Author(s)
Kunisawa, J., Yagi, K., Ikegami, K., Hamazaki, Y., Suzuki, H., Nagatake, T., Kiyono, H., Kondoh, M., Nasu, A. and Setou, M.
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Journal Title
Journal of Controlled Release
Volume: -
Pages: -
DOI
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Allograft inflammatory factor 1 (Aif1) is a regulator of transcytosis in M cells.2017
Author(s)
Kishikawa, S., Sato, S., Kaneto, S. Uchino, S., Kohsaka, S., Nakamura, S. and Kiyono, H.
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Journal Title
Nature Communications
Volume: 8
Pages: 14509
DOI
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] The spleen is the site where mast cells are induced in the development of food allergy.2017
Author(s)
Toyoshima, S., Wakamatsu, E., Ishida, Y., Obata, Y., Kurashima, Y., Kiyono, H. and Abe, R.
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Journal Title
International Immunology
Volume: -
Pages: -
DOI
Peer Reviewed / Int'l Joint Research
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[Journal Article] Nanogel-based nasal ghrelin vaccine prevents obesity.2017
Author(s)
Azegami, T., Yuki, Y., Sawada, S,, Mejima, M., Ishige, K., Akiyoshi, K., Itoh, H. and Kiyono H.
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Journal Title
Mucosal Immunology
Volume: -
Pages: -
DOI
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] E-NPP3 controls plasmacytoid dendritic cell numbers in the small intestine.2017
Author(s)
Furuta, Y., Tsai, S-H., Kinoshita, M., Fujimoto, K., Okumura, R., Umemoto, E., Kurashima, Y, Kiyono, H., Kayama, H., Takeda, K.
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Journal Title
Mucosal Immunology
Volume: 12
Pages: -
DOI
Peer Reviewed / Int'l Joint Research
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[Journal Article] Differential analyses of major allergen proteins in wild-type rice and rice producing a fragment of anti-rotavirus antibody.2016
Author(s)
Yuki, Y., Kurokawa, S., Kozuka-Hata, H., Tokuhara, D., Mejima, M., Kuroda, M., Oyama, M., Nishimaki-Mogami, T., Teshima R. and Kiyono, H.
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Journal Title
Regulatory Toxicology and Pharmacology
Volume: 76
Pages: 128-136
DOI
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] ISH NIA OS-02 attenuation of hypertension by less-invasive intranasal vaccination against angiotensin II type 1 receptor in spontaneously hypertensive rats.2016
Author(s)
Azegami, T., Yuki, Y., Hayashi, K., Nakamura, M., Hishikawa, A., Kiyono, H. and Itoh, H.
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Journal Title
Journal of Hypertension
Volume: 1
Pages: 42
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] コメ型経口ワクチンMucoRice開発プロジェクト2017
Author(s)
Kiyono H.
Organizer
Joint Symposium of The University of Tokyo and Institute of Industrial Science, Activities lead by NY Office,
Place of Presentation
Tokyo, Japan
Year and Date
2017-01-20
Int'l Joint Research / Invited
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[Book] 化学療法の領域2016
Author(s)
Kashima, K., Takeyama, N., Yuki, Y. and Kiyono, H.
Total Pages
(記載84-92）
Publisher
医薬ジャーナル社
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[Book] リンパ学会誌2016
Author(s)
Nakahashi, R., Nagatake, T. and Kiyono, H.
Total Pages
(記載80-87）
Publisher
株式会社ライフメディコム
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