2015 Fiscal Year Final Research Report
Development of rheumatoid arthritis-directed human immunology
| Project/Area Number |
23229007
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| Research Category |
Grant-in-Aid for Scientific Research (S)
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| Allocation Type | Single-year Grants |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OKAMURA TOMOHISA 東京大学, 医学部附属病院, 特任助教 (10528996)
SHODA HIROFUMI 東京大学, 医学部附属病院, 助教 (20529036)
SUMITOMO SHUJI 東京大学, 医学部附属病院, 助教 (20392996)
SHIBUYA MIHOKO 東京大学, 医学部附属病院, 助教 (20366363)
IWASAKI YUKIKO 東京大学, 医学部附属病院, 助教 (30592935)
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| Project Period (FY) |
2011-04-01 – 2016-03-31
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| Keywords | ゲノム / 内科 / 免疫学 / 組織・細胞 / 生体分子 |
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| Outline of Final Research Achievements |
This project aimed to address the function of lymphocytes in rheumatoid arthritis(RA) with regard to (1) regulatory T cells (Treg), (2) gene polymorphisms, and (3) antigen-specific CD4+ T cells. (1) TGF-beta3 producing LAG3+Treg were identified in mice and the frequency of LAG3+Treg showed a significant decrease in active RA. (2) Transcriptome and genome wide polymorphism examinations in 100 healthy controls enabled us to establish a method predicting transcriptome from genetic polymorphisms. (3) Effector and regulatory T cells recognized different BiP epitopes and their balance showed a deviation toward BiP-specific effector T cells.
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| Free Research Field |
リウマチ・アレルギー・免疫学
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