2013 Fiscal Year Final Research Report
Effect of the genetic factors to the physiological polytypisms of modern Japanese
| Project/Area Number |
23247044
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied anthropology
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| Research Institution | Kyushu University |
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Principal Investigator |
WATANUKI Shigeki 九州大学, 芸術工学研究科(研究院), 教授 (00158677)
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| Co-Investigator(Kenkyū-buntansha) |
OOTA Hiroki 北里大学, 医学部, 准教授 (40401228)
HOSHI Yoshikazu 東海大学, 農学部, 准教授 (70332088)
KONDO Ryuichiro 九州大学, 農学研究院, 特任教授 (80091370)
KIM Yonkyu 九州大学, 芸術工学研究院, 准教授 (50432886)
NISHIMURA Takayuki 長崎大学, 医歯薬学総合研究科, 助教 (80713148)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 生理的多型 / 体温調節 / 寒冷適応 / mtDNA多型 |
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| Research Abstract |
This research aimed to reveal the relationship between human physiological polytypisms and mtDNA polymorphism which was suggested to relate cold adaptation during human immigration and human metabolic diseases. Physiological responses during cold exposure and hypobaric - hypoxia exposure were mainly examined in this study. In cold exposure during 10 degrees Celsius and 16 degrees Celsius, haplotype D subjects indicated higher cold tolerance in rectal temperature and oxygen intake. In hypobaric - hypoxia exposure at 4000m, haplotype D subjects had higher SPO2 compared with other type. These results suggested that mtDNA polymorphism might affect human physiological responses and explain a part of physiological polytypisms in modern Japanese.
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