2013 Fiscal Year Final Research Report
Studies on the functional amino acid nutrition and ist application
Project/Area Number |
23248046
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Research Category |
Grant-in-Aid for Scientific Research (A)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Zootechnical science/Grassland science
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Research Institution | Kyushu University |
Principal Investigator |
FURUSE Mitsuhiro 九州大学, (連合)農学研究科(研究院), 教授 (30209176)
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Co-Investigator(Kenkyū-buntansha) |
TOMONAGA Shozo 九州大学, 大学院農学研究院, 助教 (00552324)
YASUO Shinobu 九州大学, 大学院農学研究院, 准教授 (30574719)
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Co-Investigator(Renkei-kenkyūsha) |
YASUO Shinobu 九州大学, 大学院農学研究院, 准教授 (30574719)
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Project Period (FY) |
2011-04-01 – 2014-03-31
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Keywords | ストレス / トリプトファン / アスパラギン酸 / セリン / チロシン / 不安様行動 / 受容体 / 睡眠 |
Research Abstract |
Kynurenic acid (KYNA), L-tryptophan metabolite, induced a strong sedative effect under stress via the simultaneous inhibition of the alpha 7 nicotinic acetylcholine (alpha 7nACh) receptor and N-methyl-D-aspartate (NMDA) receptor subgroup containing the subunits NR2A and NR2B. L-Aspartate (L-Asp) and D-aspartate (D-Asp) also attenuates stress responses. L-Asp could induce sedative and hypnotic effects for stress behaviors through the NMDA receptor, but D-Asp might be via simultaneous involvement of other receptors besides the NMDA receptor. Both acute and chronic L-serine treatments differently influenced an index of an antidepressant-like state. Acute L-serine increased L-serine and chronic L-serine treatment increased D-serine in the brain. The conversion of L-tyrosine to D-tyrosine in the brain of hyperactive animals may be higher, which may cause low dopamine concentration. Furthermore, L-serine, which is known as sedative factors, was lower in hyperactive animals.
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Research Products
(17 results)
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[Journal Article] The metabolism of amino acids differs between the brains of the Djungarian hamster (P. sungorus) and the Roborovskii hamster (P. roborovskii)2014
Author(s)
Ikeda, H., Kawase, T., Nagasawa, M., Chowdhury, V. S., Yasuo, S. and Furuse, M.
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Journal Title
Springer Plus
Volume: (in press)
Peer Reviewed
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[Journal Article] Oral administration of D-aspartate, but not L-aspartate, depresses rectal temperature and alters plasma metabolites in chicks2014
Author(s)
Erwan, E., Chowdhury, V.S., Nagasawa, M., Goda, R., Otsuka, T., Yasuo, S. and Furuse, M.
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Journal Title
Life Sciences
Volume: (in press)
Peer Reviewed
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[Journal Article] Central injection of L-and D-aspartate attenuates isolation induced stress behavior in chicks possibly through different mechanisms2014
Author(s)
Erwan, E., Chowdhury, V.S., Nagasawa, M., Goda, R., Otsuka, T., Yasuo, S. and Furuse, M.
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Journal Title
European Journal of Pharmacology
Volume: 736(C)
Pages: 138-142
DOI
Peer Reviewed
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[Journal Article] Hypothesis with abnormal amino acid metabolism in depression and stress vulnerability in Wistar Kyoto rats2012
Author(s)
Nagasawa, M., Ogino, Y., Kurata, K., Otsuka, T., Yoshida, J., Tomonaga, S. and Furuse, M.
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Journal Title
Amino Acids
Volume: 43(5)
Pages: 2101-2111
DOI
Peer Reviewed
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[Journal Article] Central administration of L-and D-aspartate attenuates stress behaviors by social isolation and CRF in neonatal chicks2012
Author(s)
Erwan, E., Tomonaga, S., Yoshida, J., Nagasawa, M., Ogino, Y., Denbow, D.M. and Furuse, M.
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Journal Title
Amino Acids
Volume: 43(5)
Pages: 1969-1976
DOI
Peer Reviewed
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[Journal Article] Intracerebroventricular injection of kynurenic acid attenuates corticotrophinreleasing hormone-augmented stress responses in neonatal chicks2012
Author(s)
Yoshida, J., Tomonaga, S., Ogino, Y., Nagasawa, M., Kurata, K. and Furuse, M.
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Journal Title
Neuroscience
Volume: 220(1)
Pages: 142-148
DOI
Peer Reviewed
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[Book] Functions of brain L-aspartate and its derivatives on stress responses. In: Tyrosine and Aspartic Acid: Properties, Sources and Health Benefits2012
Author(s)
Tomonaga, S., Erwan, E., Denbow, D.M. and Furuse, M.(Edited by Jones, J.E. and Morano, D.M.)
Total Pages
163-175
Publisher
NOVA Science Publishers Inc., Hauppauge NY, USA
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